- 专利标题： Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
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申请号： US10340097申请日： 2003-01-10
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公开(公告)号： US07141420B2公开(公告)日： 2006-11-28
- 发明人: Rando Allikmets , Kent L. Anderson , Michael Dean , Mark Leppert , Richard A. Lewis , Yixin Li , James R. Lupski , Jeremy Nathans , Amir Rattner , Noah F. Shroyer , Nanda Singh , Philip Smallwood , Hui Sun
- 申请人： Rando Allikmets , Kent L. Anderson , Michael Dean , Mark Leppert , Richard A. Lewis , Yixin Li , James R. Lupski , Jeremy Nathans , Amir Rattner , Noah F. Shroyer , Nanda Singh , Philip Smallwood , Hui Sun
- 申请人地址： US UT Salt Lake City US TX Houston US MD Baltiomore US DC Washington
- 专利权人： University of Utah Research Foundation,Baylor College of Medicine,John Hopkins University,The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： University of Utah Research Foundation,Baylor College of Medicine,John Hopkins University,The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US UT Salt Lake City US TX Houston US MD Baltiomore US DC Washington
- 代理机构： Woodcock Washburn LLP
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C12N15/00 ; C12N15/63 ; C07H21/02 ; C07H21/04 ; C12P21/06 ; C07K1/00
摘要：
The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
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