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    PHENYLTHIOCARBAMIDE (PTC) TASTE RECEPTOR
    1.
    发明申请
    PHENYLTHIOCARBAMIDE (PTC) TASTE RECEPTOR 有权
    苯乙烯（PTC）吸收剂

    公开(公告)号：US20100151476A1

    公开(公告)日：2010-06-17

    申请号：US12690286

    申请日：2010-01-20

    申请人： Dennis Drayna ,  Un-Kyung Kim ,  Mark Leppert

    发明人： Dennis Drayna ,  Un-Kyung Kim ,  Mark Leppert

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor.

    摘要翻译： 本发明提供了作为苯基硫代氨基甲酸（PTC）的苦味的传感器，这种PTC味觉受体的抗体，检测这种核酸和氨基酸序列的方法以及筛选方法的味细胞受体的分离的核酸和氨基酸序列 用于这种PTC味觉受体的调节剂。

    Phenylthiocarbamide (PTC) taste receptor
    2.
    发明授权
    Phenylthiocarbamide (PTC) taste receptor 有权
    苯硫代氨基甲酸（PTC）味觉受体

    公开(公告)号：US07314725B2

    公开(公告)日：2008-01-01

    申请号：US10484525

    申请日：2002-07-19

    申请人： Dennis Drayna ,  Un-Kyung Kim ,  Mark Leppert

    发明人： Dennis Drayna ,  Un-Kyung Kim ,  Mark Leppert

    IPC分类号： C07K14/705 ,  C12N15/12 ,  G01N33/566

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor.

    摘要翻译： 本发明提供了作为苯基硫代氨基甲酸（PTC）的苦味的传感器，这种PTC味觉受体的抗体，检测这种核酸和氨基酸序列的方法以及筛选方法的味细胞受体的分离的核酸和氨基酸序列 用于这种PTC味觉受体的调节剂。

    Mutant Sodium Channel Nav1.7 and Methods Related Thereto
    3.
    发明申请
    Mutant Sodium Channel Nav1.7 and Methods Related Thereto 失效
    突变型钠通道Nav1.7及其相关方法

    公开(公告)号：US20070275384A1

    公开(公告)日：2007-11-29

    申请号：US10585717

    申请日：2005-01-21

    申请人： Mark Leppert ,  Nanda Singh

    发明人： Mark Leppert ,  Nanda Singh

    IPC分类号： C07K16/18 ,  A01K67/027 ,  C07H21/04 ,  C12N1/00 ,  C12N15/85 ,  C12Q1/68 ,  C12P21/00 ,  C12N15/11 ,  C07K7/00 ,  C07K14/435

    CPC分类号： C12Q1/6883 ,  C07K14/705 ,  C12Q2600/156 ,  C12Q2600/172 ,  Y10T436/143333

    摘要： Described are mutant Nav1.7 sodium channel alpha-subunits and nucleic acid sequences encoding such mutants. Further described are methods for characterizing a nucleic acid sequence that encodes a Nav1 sodium channel alpha-subunit, methods for determining a Nav 1.7 haplotype, methods for determining a subject's predisposition to a neurologic disorder associated with a sodium channel mutation, and methods of identifying a compound that modulates mutant Nav1.7 sodium channels. Other materials, compositions, articles, devices, and methods relating to mutant Nav1.7 sodium channels are also described herein.

    摘要翻译： 描述了突变体Na + 1.7钠通道α-亚基和编码这种突变体的核酸序列。 进一步描述了用于表征编码Na + 1钠通道α-亚单位的核酸序列的方法，用于确定NaV1.7单体型的方法，用于确定受试者 与钠通道突变相关的神经障碍的倾向，以及鉴定调节突变体Na + 1.7钠通道的化合物的方法。 本文还描述了与突变体Na + 1.7钠通道相关的其它材料，组合物，制品，装置和方法。

    GENE BIOMARKERS OF LUNG FUNCTION
    5.
    发明申请
    GENE BIOMARKERS OF LUNG FUNCTION 审中-公开
    肺功能基因生物标志物

    公开(公告)号：US20130143752A1

    公开(公告)日：2013-06-06

    申请号：US13541349

    申请日：2012-07-03

    申请人： Jeffery S. Edmiston ,  Barbara K. Zedler ,  Edward Lenn Murrelle ,  Mark Leppert ,  Kellie J. Archer ,  Mariano J. Scian

    发明人： Jeffery S. Edmiston ,  Barbara K. Zedler ,  Edward Lenn Murrelle ,  Mark Leppert ,  Kellie J. Archer ,  Mariano J. Scian

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/166

    摘要： Described herein are a group of 1,013 genes and 1 phenotypic variable are identified as candidate predictors that differentiated smokers (current or former) with or without COPD. The full predictor set can be reduced to a nine-gene classifier (IL6R, CCR2, PPP2CB, RASSF2, WTAP, DNTTIP2, GDAP1, LIPE, and RPL14) with similar performance. Also described herein is the use of the full predictor set and the reduced nine gene set in methods of diagnosing lung disease or an increased risk of developing lung disease, such as COPD, in a subject. Also described herein is the use of the full predictor set and the reduced nine gene set in methods of providing a prognosis for a subject with lung disease, such as COPD.

    摘要翻译： 本文描述的是一组1,013个基因，1个表型变量被鉴定为具有或不具有COPD的吸烟者（当前或前者）的候选预测因子。 完整的预测值可以减少到具有相似性能的九基因分类器（IL6R，CCR2，PPP2CB，RASSF2，WTAP，DNTTIP2，GDAP1，LIPE和RPL14）。 本文还描述了在受试者中诊断肺部疾病或COPD发展风险增加的方法中的全部预测因子集合和减少的9个基因组的用途。 本文还描述了在为患有肺部疾病的受试者（例如COPD）提供预后的方法中使用全部预测物组和还原的九个基因集。

    APPARATUS, COMPOSITIONS, AND METHODS FOR ASSESSMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE PROGRESSION AMONG RAPID AND SLOW DECLINE CONDITIONS
    9.
    发明申请
    APPARATUS, COMPOSITIONS, AND METHODS FOR ASSESSMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE PROGRESSION AMONG RAPID AND SLOW DECLINE CONDITIONS 有权
    用于评估慢性阻塞性慢性阻塞性慢性疾病进展的装置，组合物和方法

    公开(公告)号：US20080026949A1

    公开(公告)日：2008-01-31

    申请号：US11770074

    申请日：2007-06-28

    申请人： John Hoidal ,  Mary Scholand ,  Mark Leppert ,  Michael Paul ,  Robert Gritz ,  Joel Pounds ,  Richard Smith

    发明人： John Hoidal ,  Mary Scholand ,  Mark Leppert ,  Michael Paul ,  Robert Gritz ,  Joel Pounds ,  Richard Smith

    IPC分类号： C40B20/08 ,  C40B30/00 ,  C40B40/10

    CPC分类号： C12Q1/6883 ,  G01N33/6848 ,  G01N2800/122 ,  G06F19/18

    摘要： Methods are disclosed for generating and isolating an informative content repository of respiratory related biomarkers to accurately determine whether an individual has normal or abnormal pulmonary function. Specifically, methods are directed to determination of whether individuals have chronic obstructive pulmonary disease, and if so, whether the affected individuals experience rapid long decline or slow lung decline as a result of COPD. Also disclosed is an informative content repository of chronic obstructive pulmonary disease biomarkers, which when linked with other informative content provides a powerful tool for diagnosis, study, therapeutic discovery and development, condition management, health maintenance, and linking chronic obstructive pulmonary disease through pattern of life style, environmental exposure, and genetic susceptibility and inheritance. Disclosed herein is a chronic obstructive pulmonary disease biomarker informative content repository comprising at least one COPD biomarker, apparatus and methods to diagnose, assess, address, and ameliorate related conditions.

    摘要翻译： 公开了用于产生和分离呼吸相关生物标志物的信息内容库的方法，以准确地确定个体是否具有正常或异常的肺功能。 具体来说，方法是针对确定个体是否患有慢性阻塞性肺疾病，如果是，受影响的个体是否经历COPD的快速长期衰退或肺缓慢缓慢。 还披露了慢性阻塞性肺疾病生物标志物的信息内容库，当与其他信息内容联系时，通过模式的方式为诊断，研究，治疗发现和发展，病症管理，健康维持和慢性阻塞性肺疾病连接提供了强大的工具 生活方式，环境暴露和遗传易感性和遗传。 本文公开了一种慢性阻塞性肺疾病生物标志物信息内容库，其包含至少一种COPD生物标志物，用于诊断，评估，解决和改善相关病症的装置和方法。

    PHENYLTHIOCARBAMIDE (PTC) TASTE RECEPTOR
    10.
    发明申请
    PHENYLTHIOCARBAMIDE (PTC) TASTE RECEPTOR 有权
    苯乙烯（PTC）吸收剂

    公开(公告)号：US20080227093A1

    公开(公告)日：2008-09-18

    申请号：US11871131

    申请日：2007-10-11

    申请人： Dennis Drayna ,  Un-Kyung Kim ,  Mark Leppert

    发明人： Dennis Drayna ,  Un-Kyung Kim ,  Mark Leppert

    IPC分类号： C12Q1/68

    CPC分类号： C07K14/705

    摘要： The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor.

    摘要翻译： 本发明提供了作为苯基硫代氨基甲酸（PTC）的苦味的传感器，这种PTC味觉受体的抗体，检测这种核酸和氨基酸序列的方法以及筛选方法的味细胞受体的分离的核酸和氨基酸序列 用于这种PTC味觉受体的调节剂。