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1.发明授权Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter 失效用于ATP结合盒转运蛋白的核酸和氨基酸序列以及筛选修饰ATP结合盒转运蛋白的试剂的方法公开(公告)号：US06713300B1
公开(公告)日：2004-03-30
申请号：US09032438
申请日：1998-02-27
申请人： Rando Allikmets , Kent L. Anderson , Michael Dean , Mark Leppert , Richard A. Lewis , Yixin Li , James R. Lupski , Jeremy Nathans , Amir Rattner , Noah F. Shroyer , Nanda Singh , Philip Smallwood , Hui Sun
发明人： Rando Allikmets , Kent L. Anderson , Michael Dean , Mark Leppert , Richard A. Lewis , Yixin Li , James R. Lupski , Jeremy Nathans , Amir Rattner , Noah F. Shroyer , Nanda Singh , Philip Smallwood , Hui Sun
IPC分类号： C12N1500
CPC分类号： C07K14/705 , A01K2217/05
摘要： The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
摘要翻译： 本发明提供ATP结合盒转运蛋白的核酸和氨基酸序列及其与黄斑变性相关的突变序列。 检测修饰ATP结合盒转运蛋白的试剂的方法，其包括将纯化的ATP结合盒转运蛋白与至少一种疑似修饰ATP结合盒转运蛋白的试剂组合，观察与ATP结合盒转运蛋白相关的至少一个特征的变化。 检测黄斑变性的方法也由本发明体现。
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2.发明授权
公开(公告)号：US6020189A
公开(公告)日：2000-02-01
申请号：US705245
申请日：1996-08-30
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P15/08 , A61P25/02 , A61P25/16 , A61P25/28 , A61P27/02 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07K14/50 , C07K14/52 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/02 , C12P21/08 , C12Q1/68 , C12N15/11 , C12N15/63 , C12N15/85
CPC分类号： C07K14/50 , A61K38/00 , Y10S530/806 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/813 , Y10S530/814 , Y10S530/815 , Y10S530/827
摘要： The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.
摘要翻译： 本发明提供成纤维细胞生长因子同源因子（FHF）多肽和编码它们的核酸分子。 本发明还包括使用FHF多肽和核酸的诊断和治疗方法。
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公开(公告)号：US20070066812A1
公开(公告)日：2007-03-22
申请号：US11514821
申请日：2006-09-01
申请人： Jeremy Nathans , Philip Smallwood , Jennifer Macke
发明人： Jeremy Nathans , Philip Smallwood , Jennifer Macke
IPC分类号： C07K16/22
摘要： A novel growth factor, fibroblast growth factor homologous factor-2 (FHF-2) polypeptide, the polynucleotide sequence encoding FHF-2 and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-2 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-2.
摘要翻译： 公开了一种新的生长因子，成纤维细胞生长因子同源因子-2（FHF-2）多肽，编码FHF-2的多核苷酸序列和推定的氨基酸序列。 还公开了使用FHF-2多肽和特异性结合FHF-2的多核苷酸序列和抗体的诊断和治疗方法。
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4.发明授权Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter 有权使用核酸序列进行ATP结合盒转运蛋白的基因治疗方法公开(公告)号：US07192579B2
公开(公告)日：2007-03-20
申请号：US10336219
申请日：2003-01-03
申请人： Rando Allikmets , Kent L. Anderson , Michael Dean , Mark Leppert , Richard A. Lewis , Yixin Li , James R. Lupski , Jeremy Nathans , Amir Rattner , Noah F. Shroyer , Nanda Singh , Philip Smallwood , Hui Sun
发明人： Rando Allikmets , Kent L. Anderson , Michael Dean , Mark Leppert , Richard A. Lewis , Yixin Li , James R. Lupski , Jeremy Nathans , Amir Rattner , Noah F. Shroyer , Nanda Singh , Philip Smallwood , Hui Sun
CPC分类号： C07K14/705 , A01K2217/05
摘要： The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
摘要翻译： 本发明提供ATP结合盒转运蛋白的核酸和氨基酸序列及其与黄斑变性相关的突变序列。 检测修饰ATP结合盒转运蛋白的试剂的方法，其包括将纯化的ATP结合盒转运蛋白与至少一种疑似修饰ATP结合盒转运蛋白的试剂组合，观察与ATP结合盒转运蛋白相关的至少一个特征的变化。 检测黄斑变性的方法也由本发明体现。
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5.发明授权公开(公告)号：US07189511B2
公开(公告)日：2007-03-13
申请号：US10336215
申请日：2003-01-03
申请人： Rando Allikmets , Kent L. Anderson , Michael Dean , Mark Leppert , Richard A. Lewis , Yixin Li , James R. Lupski , Jeremy Nathans , Amir Rattner , Noah F. Shroyer , Nanda Singh , Philip Smallwood , Hui Sun
发明人： Rando Allikmets , Kent L. Anderson , Michael Dean , Mark Leppert , Richard A. Lewis , Yixin Li , James R. Lupski , Jeremy Nathans , Amir Rattner , Noah F. Shroyer , Nanda Singh , Philip Smallwood , Hui Sun
CPC分类号： C07K14/705 , A01K2217/05
摘要： The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
摘要翻译： 本发明提供ATP结合盒转运蛋白的核酸和氨基酸序列及其与黄斑变性相关的突变序列。 检测修饰ATP结合盒转运蛋白的试剂的方法，其包括将纯化的ATP结合盒转运蛋白与至少一种疑似修饰ATP结合盒转运蛋白的试剂组合，观察与ATP结合盒转运蛋白相关的至少一个特征的变化。 检测黄斑变性的方法也由本发明体现。
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公开(公告)号：US07141420B2
公开(公告)日：2006-11-28
申请号：US10340097
申请日：2003-01-10
申请人： Rando Allikmets , Kent L. Anderson , Michael Dean , Mark Leppert , Richard A. Lewis , Yixin Li , James R. Lupski , Jeremy Nathans , Amir Rattner , Noah F. Shroyer , Nanda Singh , Philip Smallwood , Hui Sun
发明人： Rando Allikmets , Kent L. Anderson , Michael Dean , Mark Leppert , Richard A. Lewis , Yixin Li , James R. Lupski , Jeremy Nathans , Amir Rattner , Noah F. Shroyer , Nanda Singh , Philip Smallwood , Hui Sun
CPC分类号： C07K14/705 , A01K2217/05
摘要： The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.
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公开(公告)号：US06635744B1
公开(公告)日：2003-10-21
申请号：US09490714
申请日：2000-01-25
IPC分类号： A61K3824
CPC分类号： C07K14/50 , A61K38/00 , Y10S530/806 , Y10S530/81 , Y10S530/811 , Y10S530/812 , Y10S530/813 , Y10S530/814 , Y10S530/815 , Y10S530/827
摘要： The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.
摘要翻译： 本发明提供成纤维细胞生长因子同源因子（FHF）多肽和编码它们的核酸分子。 本发明还包括使用FHF多肽和核酸的诊断和治疗方法。
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公开(公告)号：US5876967A
公开(公告)日：1999-03-02
申请号：US438439
申请日：1995-05-12
IPC分类号： G01N33/50 , A61K9/127 , A61K35/76 , A61K38/00 , A61K39/395 , A61K48/00 , A61P35/00 , C07K14/475 , C07K14/50 , C07K16/22 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , G01N33/15 , C12N15/00 , C07H21/04 , C12N15/63 , C12N15/82
摘要： A novel growth factor, fibroblast growth factor homologous factor-2 (FHF-2) polypeptide, the polynucleotide sequence encoding FHF-2 and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-2 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-2.
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公开(公告)号：US5872226A
公开(公告)日：1999-02-16
申请号：US867471
申请日：1997-06-02
IPC分类号： G01N33/577 , A61K9/127 , A61K31/70 , A61K35/76 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61K49/00 , A61P25/00 , A61P27/02 , A61P35/00 , C07K14/50 , C07K16/22 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/15 , C07K14/475 , A61K38/18
CPC分类号： C07K16/22 , C07K14/50 , C12Q1/6886 , A61K38/00 , C12Q2600/158
摘要： A novel protein, fibroblast growth factor homologous factor-1 (FHF-1), the polynucleotide sequence encoding FHF-1, and the deduced amino acid sequence are disclosed. Also disclosed are diagnostic and therapeutic methods of using the FHF-1 polypeptide and polynucleotide sequences and antibodies which specifically bind to FHF-1.
摘要翻译： 公开了一种新型蛋白质，成纤维细胞生长因子同源因子-1（FHF-1），编码FHF-1的多核苷酸序列和推定的氨基酸序列。 还公开了使用FHF-1多肽和特异性结合FHF-1的多核苷酸序列和抗体的诊断和治疗方法。
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公开(公告)号：US20070269808A1
公开(公告)日：2007-11-22
申请号：US11370191
申请日：2006-03-06
申请人： Purnima Bhanot , Marcel Brink , Cindy Samos , Yanshu Wang , Jen-Chih Hsieh , Deborah Andrew , Jeremy Nathans , Roeland Nusse
发明人： Purnima Bhanot , Marcel Brink , Cindy Samos , Yanshu Wang , Jen-Chih Hsieh , Deborah Andrew , Jeremy Nathans , Roeland Nusse
CPC分类号： C07K14/71 , C07K14/43581 , G01N33/74 , G01N2333/43573 , G01N2500/00
摘要： Wnt receptor compositions and methods of use are disclosed. In particular, methods using Wnt receptors, such as Dfz2, in screens for compounds which modulate the binding of a Wnt polypeptide to a Wnt receptor.
摘要翻译： 公开了Wnt受体组合物和使用方法。 特别地，使用Wnt受体（例如Dfz2）在筛选调节Wnt多肽与Wnt受体的结合的化合物的方法。
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