发明授权
- 专利标题: Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications
- 专利标题(中): 非咪唑烷基胺作为组胺H3受体配体及其治疗应用
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申请号: US10856838申请日: 2004-06-01
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公开(公告)号: US07169928B2公开(公告)日: 2007-01-30
- 发明人: Jean-Charles Schwartz , Jean-Michel Arrang , Monique Garbarg , Jeanne-Marie Lecomte , Xavier Ligneau , Walter G. Schunack , Holger Stark , Charon Robin Ganellin , Fabien Leurquin , Sigurd Elz
- 申请人: Jean-Charles Schwartz , Jean-Michel Arrang , Monique Garbarg , Jeanne-Marie Lecomte , Xavier Ligneau , Walter G. Schunack , Holger Stark , Charon Robin Ganellin , Fabien Leurquin , Sigurd Elz
- 申请人地址: FR Paris
- 专利权人: Societe Civile Bioproject
- 当前专利权人: Societe Civile Bioproject
- 当前专利权人地址: FR Paris
- 代理机构: Stites & Harbison PLLC
- 代理商 B. Aaron Schulman
- 优先权: EP98401944 19980729; EP98403351 19981231
- 主分类号: C07D211/56
- IPC分类号: C07D211/56 ; C07D211/20 ; C07D207/08 ; A61K31/445
摘要:
Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H3-receptors when attached to an imidazole ring in 4(5) position; R1 and R2 may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H3-receptors of histamine.
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