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发明授权
US07175840B2 Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof 失效
用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分

Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
摘要：
The present invention relates to the compositions for a gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof. More specifically, the present invention provides a gene therapy of rheumatoid arthritis by preparing a recombinant vector that expresses a gene encoding an anti-angiogenic protein such as angiostatin or parts thereof, and transplanting the recombinant vector or a cell that is transfected or transduced with the recombinant vector into the affected area of a patient, and also provides the compositions for the gene therapy. The compositions for the gene therapy according to the present invention can be used effectively for the treatment of rheumatoid arthritis, for which effective treating methods have not been developed until now, by providing the anti-angiogenic proteins into the knee of a patient continuously to prevent the synovial tissue hyperplasia and the resulting inflammation.
摘要（中）：

本发明涉及用于类风湿性关节炎基因治疗的组合物，包括编码抗血管生成蛋白质的基因或其部分。 更具体地，本发明通过制备表达编码抗血管生成蛋白质的基因的重组载体，例如血管抑素或其部分，提供类风湿性关节炎的基因治疗，并移植重组载体或转染或转导的细胞 重组载体进入患者的受影响区域，并且还提供用于基因治疗的组合物。 根据本发明的基因治疗组合物可以有效地用于治疗类风湿性关节炎，通过将抗血管生成蛋白质连续地提供给患者的膝盖以防止其发生，迄今尚未开发出有效的治疗方法 滑膜组织增生和由此引起的炎症。

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