发明授权
- 专利标题： Compositions and methods for hydroxylating epothilones
- 专利标题（中）： 用于羟化埃坡霉素的组合物和方法
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申请号： US10915172申请日： 2004-08-09
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公开(公告)号： US07214527B2公开(公告)日： 2007-05-08
- 发明人: Jonathan David Basch , Shu-Jen David Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
- 申请人： Jonathan David Basch , Shu-Jen David Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Paul D. Golian
- 主分类号： C12N1/20
- IPC分类号： C12N1/20 ; C12N15/74 ; C07H21/04
摘要：
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
公开/授权文献
- US20050208620A1 Compositions and methods for hydroxylating epothilones 公开/授权日：2005-09-22
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