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公开(公告)号：US06884608B2
公开(公告)日：2005-04-26
申请号：US10321188
申请日：2002-12-17
申请人： Jonathan David Basch , Shu-Jen David Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
发明人： Jonathan David Basch , Shu-Jen David Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
CPC分类号： C12N9/0077 , C07K14/79 , C07K2299/00 , C12P17/181
摘要： Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
摘要翻译： 提供了分离的核酸序列和由此编码的用于埃坡霉素B羟化酶及其突变体和变体以及位于埃坡霉素B羟化酶基因下游的铁氧还蛋白的多肽。 还提供了含有这些载体的载体和细胞。 此外，提供了用于制备重组微生物的方法，使用这些重组微生物制备含有羟烷基的埃坡霉素的方法和由埃坡霉素B羟化酶的突变体产生的埃坡霉素类似物。
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公开(公告)号：US07214527B2
公开(公告)日：2007-05-08
申请号：US10915172
申请日：2004-08-09
申请人： Jonathan David Basch , Shu-Jen David Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
发明人： Jonathan David Basch , Shu-Jen David Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
CPC分类号： C12N9/0077 , C07K14/79 , C07K2299/00 , C12P17/181
摘要： Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
摘要翻译： 提供了分离的核酸序列和由此编码的用于埃坡霉素B羟化酶及其突变体和变体以及位于埃坡霉素B羟化酶基因下游的铁氧还蛋白的多肽。 还提供了含有这些载体的载体和细胞。 此外，提供了用于制备重组微生物的方法，使用这些重组微生物制备含有羟烷基的埃坡霉素的方法和由埃坡霉素B羟化酶的突变体产生的埃坡霉素类似物。
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公开(公告)号：US20050208620A1
公开(公告)日：2005-09-22
申请号：US10915172
申请日：2004-08-09
申请人： Jonathan Basch , Shu-Jen Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
发明人： Jonathan Basch , Shu-Jen Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
CPC分类号： C12N9/0077 , C07K14/79 , C07K2299/00 , C12P17/181
摘要： Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
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