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公开(公告)号：US07214527B2
公开(公告)日：2007-05-08
申请号：US10915172
申请日：2004-08-09
申请人： Jonathan David Basch , Shu-Jen David Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
发明人： Jonathan David Basch , Shu-Jen David Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
CPC分类号： C12N9/0077 , C07K14/79 , C07K2299/00 , C12P17/181
摘要： Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
摘要翻译： 提供了分离的核酸序列和由此编码的用于埃坡霉素B羟化酶及其突变体和变体以及位于埃坡霉素B羟化酶基因下游的铁氧还蛋白的多肽。 还提供了含有这些载体的载体和细胞。 此外，提供了用于制备重组微生物的方法，使用这些重组微生物制备含有羟烷基的埃坡霉素的方法和由埃坡霉素B羟化酶的突变体产生的埃坡霉素类似物。
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公开(公告)号：US06884608B2
公开(公告)日：2005-04-26
申请号：US10321188
申请日：2002-12-17
申请人： Jonathan David Basch , Shu-Jen David Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
发明人： Jonathan David Basch , Shu-Jen David Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
CPC分类号： C12N9/0077 , C07K14/79 , C07K2299/00 , C12P17/181
摘要： Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
摘要翻译： 提供了分离的核酸序列和由此编码的用于埃坡霉素B羟化酶及其突变体和变体以及位于埃坡霉素B羟化酶基因下游的铁氧还蛋白的多肽。 还提供了含有这些载体的载体和细胞。 此外，提供了用于制备重组微生物的方法，使用这些重组微生物制备含有羟烷基的埃坡霉素的方法和由埃坡霉素B羟化酶的突变体产生的埃坡霉素类似物。
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公开(公告)号：US20050208620A1
公开(公告)日：2005-09-22
申请号：US10915172
申请日：2004-08-09
申请人： Jonathan Basch , Shu-Jen Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
发明人： Jonathan Basch , Shu-Jen Chiang , Suo-Win Liu , Akbar Nayeem , Yuhua Sun , Li You
CPC分类号： C12N9/0077 , C07K14/79 , C07K2299/00 , C12P17/181
摘要： Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
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公开(公告)号：US20130045197A1
公开(公告)日：2013-02-21
申请号：US13588210
申请日：2012-08-17
申请人： Manasi Chavan , Yuhua Sun , Christine Williams , Michael Sunkin
发明人： Manasi Chavan , Yuhua Sun , Christine Williams , Michael Sunkin
摘要： The present invention relates to a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising the broth obtained by inoculating a biomass of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, with a yeast culture, and allowing fermentation of the biomass to produce a fermentation broth. Also described is a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising an extract of the algae, Gracilaria tikvahiae. The present invention also relates to topical compositions comprising as a a cosmetic and/or pharmaceutical active component a ferment of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, or an extract of the algae, Gracilaria tikvahiae, or a combination of both.
摘要翻译： 本发明涉及一种用于刺激皮肤细胞的蛋白酶体活性的化妆品和/或药物活性成分，其包含通过用酵母培养物接种藻类，江ia，特别是藻类，马鞭草属的生物质获得的肉汤，并允许 发酵生物质以产生发酵液。 还描述了一种用于刺激皮肤细胞的蛋白酶体活性的化妆品和/或药物活性成分，其包括藻类提取物，江孜草。 本发明还涉及包含作为化妆品和/或药物活性成分的化妆品和/或药物活性成分的发酵，藻类，江ia，特别是藻类，山楂，或藻类提取物，山茱萸，或两者的组合 。
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公开(公告)号：US09480864B2
公开(公告)日：2016-11-01
申请号：US13588210
申请日：2012-08-17
申请人： Manasi Chavan , Yuhua Sun , Christine Williams , Michael Sunkin
发明人： Manasi Chavan , Yuhua Sun , Christine Williams , Michael Sunkin
摘要： The present invention relates to a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising the broth obtained by inoculating a biomass of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, with a yeast culture, and allowing fermentation of the biomass to produce a fermentation broth. Also described is a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising an extract of the algae, Gracilaria tikvahiae. The present invention also relates to topical compositions comprising as a cosmetic and/or pharmaceutical active component a ferment of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, or an extract of the algae, Gracilaria tikvahiae, or a combination of both.
摘要翻译： 本发明涉及一种用于刺激皮肤细胞的蛋白酶体活性的化妆品和/或药物活性成分，其包含通过用酵母培养物接种藻类，江ia，特别是藻类，马鞭草属的生物质获得的肉汤，并允许 发酵生物质以产生发酵液。 还描述了一种用于刺激皮肤细胞的蛋白酶体活性的化妆品和/或药物活性成分，其包括藻类提取物，江孜草。 本发明还涉及包含作为化妆品和/或药物活性成分的藻类，江ia（Gracilaria spp。），特别是藻类，山楂（Tacvahiae）或藻类提取物，山楂（Tacvahiae）或两者的组合的发酵物的局部组合物 。
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