发明授权
- 专利标题： Avidin derivatives and uses thereof
- 专利标题（中）： 抗生物素蛋白衍生物及其用途
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申请号： US10624503申请日： 2003-07-23
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公开(公告)号： US07217575B2公开(公告)日： 2007-05-15
- 发明人: Meir Wilchek , Edward A Bayer , Heike Hofstetter , Margherita Morpurgo
- 申请人： Meir Wilchek , Edward A Bayer , Heike Hofstetter , Margherita Morpurgo
- 申请人地址： IL Rehovot
- 专利权人： Yeda Research and Development Co. Ltd.
- 当前专利权人： Yeda Research and Development Co. Ltd.
- 当前专利权人地址： IL Rehovot
- 代理机构： Browdy & Neimark, PLLC
- 优先权： IL126990 19981110
- 主分类号： G01N33/545
- IPC分类号： G01N33/545 ; G01N33/53 ; G01N33/552 ; G01N33/553 ; C07K16/44
摘要：
A covalent conjugate of a 4′-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula: wherein A is (CH2)n or —CH═CH—, wherein n is an integer from 0–10; B is (CH2)n wherein n is an integer from 2 to 10; m is zero or 1; and Av is the residue of an avidin-type molecule selected from the group comprising native egg-white avidin, recombinant avidin, deglycosylated avidins, bacterial streptavidin, recombinant streptavidin, truncated streptavidin and other derivatives of said avidin-type molecules. These HABAylated avidins are red colored in the quinone configuration and can be used in many applications in the avidin-biotin technology.
公开/授权文献
- US20040191832A1 Avidin derivatives and uses thereof 公开/授权日：2004-09-30
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