发明授权
- 专利标题： Preparation of (E)- and (Z)-2-methyl-2-butenoic acids
- 专利标题（中）： （E） - 和（Z）-2-甲基-2-丁烯酸的制备
-
申请号： US11585036申请日： 2006-10-23
-
公开(公告)号： US07285410B2公开(公告)日： 2007-10-23
- 发明人: Michael G. Bramucci , Robert DiCosimo , Sarita Chauhan , Robert D. Fallon , John E. Gavagan , Mark S. Payne
- 申请人： Michael G. Bramucci , Robert DiCosimo , Sarita Chauhan , Robert D. Fallon , John E. Gavagan , Mark S. Payne
- 申请人地址： US DE Wilmington
- 专利权人： E. I. du Pont de Nemours and Company
- 当前专利权人： E. I. du Pont de Nemours and Company
- 当前专利权人地址： US DE Wilmington
- 主分类号： C12N1/20
- IPC分类号： C12N1/20 ; C12N9/78 ; C12N9/88 ; C12N15/00 ; C12Q1/34 ; C07K14/00 ; C07H21/04
摘要：
A method has been developed to prepare (E)- and (Z)-2-methyl-2-butenoic acids (2M2BA) from a mixture of (E,Z)-2-methyl-2-butenenitriles (2M2BN) by the regioselective hydrolysis of (E)-2M2BN to (E)-2-methyl-2-butenoic acid (2M2BA) using enzyme catalysts having either a nitrilase activity or a combination of nitrile hydratase and amidase activities. The method provides high yields without significant conversion of (Z)-2M2BN to (Z)-2M2BA. The regioselective hydrolysis of (E)-2M2BN to (E)-2M2BA makes possible the facile separation of (E)-2M2BA from (Z)-2M2BN or (Z)-2-methyl-2-butenamide (2M2BAm), and the subsequent conversion of (Z)-2M2BN or (Z)-2M2BAm to (Z)-2M2BA.
公开/授权文献
- US20070037264A1 Preparation of (E)- and (Z)-2-methyl-2-butenoic acids 公开/授权日：2007-02-15