发明授权
US07358347B1 MEN1, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof
失效
MEN1，与多发性内分泌肿瘤1型有关的基因，menin多肽及其用途
- 专利标题： MEN1, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof
- 专利标题（中）： MEN1，与多发性内分泌肿瘤1型有关的基因，menin多肽及其用途
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申请号： US09380337申请日： 1998-03-04
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公开(公告)号： US07358347B1公开(公告)日： 2008-04-15
- 发明人: Settara Chandrasekharappa , Siradanahalli Guru , Pachiappan Manickam , Francis S. Collins , Michael R. Emmert-Buck , Larisa V. Debelenko , Irina A. Lubensky , Lance A. Liotta , Sunita K. Agarwal , Allen M. Spiegel , A. Lee Burns , Stephen J. Marx , Zhengping Zhuang
- 申请人： Settara Chandrasekharappa , Siradanahalli Guru , Pachiappan Manickam , Francis S. Collins , Michael R. Emmert-Buck , Larisa V. Debelenko , Irina A. Lubensky , Lance A. Liotta , Sunita K. Agarwal , Allen M. Spiegel , A. Lee Burns , Stephen J. Marx , Zhengping Zhuang
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Townsend and Townsend and Crew LLP
- 国际申请： PCT/US98/04258 WO 19980304
- 国际公布： WO98/39439 WO 19980911
- 主分类号： C07H21/00
- IPC分类号： C07H21/00 ; C07H21/02 ; C07H21/04 ; C12Q1/68 ; C12P19/26 ; C12P19/34
摘要：
The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.
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