公开(公告)号：US07358347B1

公开(公告)日：2008-04-15

申请号：US09380337

申请日：1998-03-04

申请人： Settara Chandrasekharappa ,  Siradanahalli Guru ,  Pachiappan Manickam ,  Francis S. Collins ,  Michael R. Emmert-Buck ,  Larisa V. Debelenko ,  Irina A. Lubensky ,  Lance A. Liotta ,  Sunita K. Agarwal ,  Allen M. Spiegel ,  A. Lee Burns ,  Stephen J. Marx ,  Zhengping Zhuang

发明人： Settara Chandrasekharappa ,  Siradanahalli Guru ,  Pachiappan Manickam ,  Francis S. Collins ,  Michael R. Emmert-Buck ,  Larisa V. Debelenko ,  Irina A. Lubensky ,  Lance A. Liotta ,  Sunita K. Agarwal ,  Allen M. Spiegel ,  A. Lee Burns ,  Stephen J. Marx ,  Zhengping Zhuang

IPC分类号： C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68 ,  C12P19/26 ,  C12P19/34

CPC分类号： C12Q1/6886 ,  C12Q2600/156

摘要： The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.

摘要翻译： 本发明涉及一种与多发性内分泌肿瘤1型相关的新型肿瘤抑制基因的发现。该基因被命名为MEN1，该基因产物是menin。 在具有1型多发性内分泌肿瘤1型的个体中已经鉴定了相应基因中不存在该蛋白质和相关突变。鉴定该多重内分泌肿瘤1型的该标志物具有诊断用途以及基因治疗。