发明授权
US07510706B2 Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity
有权
含有具有血凝素活性的膜蛋白的假型逆转录病毒载体
- 专利标题： Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity
- 专利标题（中）： 含有具有血凝素活性的膜蛋白的假型逆转录病毒载体
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申请号： US10306949申请日： 2002-11-29
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公开(公告)号： US07510706B2公开(公告)日： 2009-03-31
- 发明人: Yoshikazu Yonemitsu , Toshihiro Nakajima , Kenji Nakamaru , Masanori Kobayashi , Mamoru Hasegawa , Yasuji Ueda , Akihiro Iida , Hiroyuki Sakakibara
- 申请人： Yoshikazu Yonemitsu , Toshihiro Nakajima , Kenji Nakamaru , Masanori Kobayashi , Mamoru Hasegawa , Yasuji Ueda , Akihiro Iida , Hiroyuki Sakakibara
- 申请人地址： JP Ibaraki
- 专利权人： DNAVEC Research Inc.
- 当前专利权人： DNAVEC Research Inc.
- 当前专利权人地址： JP Ibaraki
- 代理机构： Clark & Elbing LLP
- 优先权： JP2000-169090 20000601
- 主分类号： A01N63/00
- IPC分类号： A01N63/00 ; A61K48/00 ; C12N5/00 ; C12N15/00 ; A61K31/70
摘要：
The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane protein having a hemagglutinin activity. This viral vector showed gene transfer at a high efficiency into host cells. In particular, it was established that genes can be transferred thereby at a high efficiency into cells into which genes can hardly be transferred by the conventional techniques, for example, blood cells and hematopoietic cells including hematopoietic stem cells, and mucous cells including mucosa epithelial cells. The viral vector of the present invention is highly useful as a vector for gene therapy.
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