发明授权
US07678798B2 Piperazinylpiperidine derivatives as chemokine receptor antagonists
有权
哌嗪基哌啶衍生物作为趋化因子受体拮抗剂
- 专利标题： Piperazinylpiperidine derivatives as chemokine receptor antagonists
- 专利标题（中）： 哌嗪基哌啶衍生物作为趋化因子受体拮抗剂
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申请号： US11104041申请日： 2005-04-12
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公开(公告)号： US07678798B2公开(公告)日： 2010-03-16
- 发明人: Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
- 申请人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
- 申请人地址： US DE Wilmington
- 专利权人： Incyte Corporation
- 当前专利权人： Incyte Corporation
- 当前专利权人地址： US DE Wilmington
- 代理机构： Fish & Richardson P.C.
- 代理商 Christine A. Goddard
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; C07D247/02 ; A61K31/496 ; A61P29/00 ; C07D237/28 ; C07D487/00 ; C07D401/04 ; C07D403/04 ; C07D405/04 ; C07D409/04 ; C07D411/04 ; C07D413/04 ; C07D417/04 ; C07D419/04 ; C07D241/04 ; C07D277/22 ; C07D307/78 ; C07D303/08 ; C07C49/297 ; C07C33/46
摘要：
The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
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