-
公开(公告)号：US20120295912A1
公开(公告)日：2012-11-22
申请号：US13564434
申请日：2012-08-01
申请人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
发明人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
IPC分类号： A61K31/506 , A61K31/496 , A61P29/00 , C12N5/071 , A61P31/12 , A61P31/18 , A61P37/06 , A61K31/502 , A61P37/00
CPC分类号： C07D401/14 , A61K31/496 , A61K31/502 , A61K31/506 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
摘要翻译： 本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。 在一些实施方案中，本发明的化合物对CCR5是选择性的。 该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。
-
公开(公告)号：US07678798B2
公开(公告)日：2010-03-16
申请号：US11104041
申请日：2005-04-12
申请人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
发明人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
IPC分类号： A61K31/497 , C07D247/02 , A61K31/496 , A61P29/00 , C07D237/28 , C07D487/00 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D411/04 , C07D413/04 , C07D417/04 , C07D419/04 , C07D241/04 , C07D277/22 , C07D307/78 , C07D303/08 , C07C49/297 , C07C33/46
CPC分类号： C07D401/14 , A61K31/496 , A61K31/502 , A61K31/506 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
摘要翻译： 本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。 在一些实施方案中，本发明的化合物对CCR5是选择性的。 该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。
-
公开(公告)号：US08268826B2
公开(公告)日：2012-09-18
申请号：US12422517
申请日：2009-04-13
申请人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
发明人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
IPC分类号： A61P29/00 , A61P31/12 , A61P37/00 , C07D237/28 , C07D401/14 , A61K31/502 , C07D403/14 , A61K31/501
CPC分类号： C07D401/14 , A61K31/496 , A61K31/502 , A61K31/506 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
摘要翻译： 本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。 在一些实施方案中，本发明的化合物对CCR5是选择性的。 该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。
-
公开(公告)号：US20050261310A1
公开(公告)日：2005-11-24
申请号：US11104041
申请日：2005-04-12
申请人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian Metcalf
发明人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David Meloni , Rajan Anand , Joseph Glenn , Brian Metcalf
IPC分类号： A61K31/496 , A61K45/06 , C07D401/06 , C07D401/14 , C07D417/14 , C07D471/04 , C07D43/04
CPC分类号： C07D401/14 , A61K31/496 , A61K31/502 , A61K31/506 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
摘要翻译： 本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。 在一些实施方案中，本发明的化合物对CCR5是选择性的。 该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。
-
公开(公告)号：US20140155404A1
公开(公告)日：2014-06-05
申请号：US14176781
申请日：2014-02-10
申请人： Chu-Biao Xue , Genfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David J. Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
发明人： Chu-Biao Xue , Genfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David J. Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
IPC分类号： C07D401/14 , C07D417/14 , A61K31/496 , C07D471/04 , A61K31/506 , A61K31/502
CPC分类号： C07D401/14 , A61K31/496 , A61K31/502 , A61K31/506 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
摘要翻译： 本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。 在一些实施方案中，本发明的化合物对CCR5是选择性的。 该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。
-
公开(公告)号：US08680104B2
公开(公告)日：2014-03-25
申请号：US13564434
申请日：2012-08-01
申请人： Chu-Biao Xue , Genfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David J. Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
发明人： Chu-Biao Xue , Genfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David J. Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
IPC分类号： A61K31/497
CPC分类号： C07D401/14 , A61K31/496 , A61K31/502 , A61K31/506 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
摘要翻译： 本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。 在一些实施方案中，本发明的化合物对CCR5是选择性的。 该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。
-
7.发明授权3-(4-heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors 有权3-（4-杂芳基环己基氨基）环戊烷甲酰胺作为趋化因子受体的调节剂公开(公告)号：US07307086B2
公开(公告)日：2007-12-11
申请号：US11125647
申请日：2005-05-10
申请人： Chu-Biao Xue , Changsheng Zheng , Ganfeng Cao , Hao Feng , Michael Xia , Rajan Anand , Joseph Glenn , Brian W. Metcalf
发明人： Chu-Biao Xue , Changsheng Zheng , Ganfeng Cao , Hao Feng , Michael Xia , Rajan Anand , Joseph Glenn , Brian W. Metcalf
IPC分类号： C07D471/02 , A61K31/47
CPC分类号： C07D471/04 , C07D217/06 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
摘要翻译： 本发明涉及式I化合物：其是趋化因子受体的调节剂。 本发明的化合物及其组合物可用于治疗与趋化因子受体表达和/或活性相关的疾病。
-
8.发明申请公开(公告)号：US20100119503A1
公开(公告)日：2010-05-13
申请号：US12238121
申请日：2008-09-25
申请人： Chu-Biao Xue , Changsheng Zheng , Hao Feng , Michael Xia , Joseph Glenn , Ganfeng Cao , Brian W. Metcalf
发明人： Chu-Biao Xue , Changsheng Zheng , Hao Feng , Michael Xia , Joseph Glenn , Ganfeng Cao , Brian W. Metcalf
IPC分类号： A61K39/395 , C07D405/12 , C07D405/14 , A61K31/496 , A61K31/4433 , A61K31/444 , A61K31/506 , A61P9/10 , A61P3/10 , A61P3/04 , A61P19/02 , A61P37/06 , A61P25/14 , A61P25/00 , A61P29/00
CPC分类号： C07D405/14 , C07D309/14 , C07D405/12
摘要： The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
摘要翻译： 本发明涉及式I化合物：其是趋化因子受体的调节剂。 本发明的化合物及其组合物可用于治疗与趋化因子受体表达和/或活性相关的疾病。
-
9.发明授权公开(公告)号：US07618970B2
公开(公告)日：2009-11-17
申请号：US11167329
申请日：2005-06-27
申请人： Chu-Biao Xue , Changsheng Zheng , Hao Feng , Michael Xia , Joseph Glenn , Ganfeng Cao , Brian W. Metcalf
发明人： Chu-Biao Xue , Changsheng Zheng , Hao Feng , Michael Xia , Joseph Glenn , Ganfeng Cao , Brian W. Metcalf
IPC分类号： A61K31/497 , A61K31/445 , C07D403/08 , C07D295/23 , C07D401/08
CPC分类号： C07D309/14 , C07D405/12 , C07D405/14
摘要： The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
摘要翻译： 本发明涉及式I化合物：其是趋化因子受体的调节剂。 本发明的化合物及其组合物可用于治疗与趋化因子受体表达和/或活性相关的疾病。
-
10.发明授权公开(公告)号：US07449467B2
公开(公告)日：2008-11-11
申请号：US11167816
申请日：2005-06-27
申请人： Chu-Biao Xue , Changsheng Zheng , Hao Feng , Michael Xia , Joseph Glenn , Ganfeng Cao , Brian W. Metcalf
发明人： Chu-Biao Xue , Changsheng Zheng , Hao Feng , Michael Xia , Joseph Glenn , Ganfeng Cao , Brian W. Metcalf
IPC分类号： A61K31/497 , A61K31/445 , C07D403/12 , C07D241/04 , C07D211/02
CPC分类号： C07D405/14 , C07D309/14 , C07D405/12
摘要： The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.
摘要翻译： 本发明涉及式I化合物：其是趋化因子受体的调节剂。 本发明的化合物及其组合物可用于治疗与趋化因子受体表达和/或活性相关的疾病。
-
-
-
-
-
-
-
-
-
搜索结果
29 条记录 (耗时 0.048 秒)
