Invention Grant
US07709239B2 Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
有权
突变和Dgr; 8去饱和酶基因通过靶向诱变工程改造，并用于制备多不饱和脂肪酸
- Patent Title: Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
- Patent Title (中): 突变和Dgr; 8去饱和酶基因通过靶向诱变工程改造，并用于制备多不饱和脂肪酸
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Application No.: US11635258Application Date: 2006-12-07
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Publication No.: US07709239B2Publication Date: 2010-05-04
- Inventor: Howard Glenn Damude , Hongxian He , Der-Ing Liao , Quinn Qun Zhu
- Applicant: Howard Glenn Damude , Hongxian He , Der-Ing Liao , Quinn Qun Zhu
- Applicant Address: US DE Wilmington
- Assignee: E.I. du Pont de Nemours and Company
- Current Assignee: E.I. du Pont de Nemours and Company
- Current Assignee Address: US DE Wilmington
- Agent Lynne M. Christenbury
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C12Q1/26 ; C12N15/00 ; C12P7/64 ; C12N5/04 ; C12N5/10 ; C12N1/21 ; C12N1/15 ; C12N1/19 ; C07H21/00 ; C12N9/02 ; C07K14/00
Abstract:
The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these mutant Δ8 desaturases in plants and oleaginous yeast are disclosed.
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