发明授权
US07812019B2 Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof
有权
抑制香草素受体亚型1（VR1）受体的丝氨酸脲化合物及其用途
- 专利标题： Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof
- 专利标题（中）： 抑制香草素受体亚型1（VR1）受体的丝氨酸脲化合物及其用途
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申请号： US11285448申请日： 2005-11-22
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公开(公告)号： US07812019B2公开(公告)日： 2010-10-12
- 发明人: Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, Jr. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
- 申请人： Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, Jr. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
- 申请人地址： US IL Abbott Park
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： US IL Abbott Park
- 代理商 Andrew M. Parial
- 主分类号： A61K31/5375
- IPC分类号： A61K31/5375 ; A61K31/47 ; A61K31/445 ; A61K31/415 ; A61K31/35 ; C07D413/00 ; C07D217/00 ; C07D215/00 ; C07D211/00 ; C07D231/56 ; C07D311/00
摘要：
Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
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