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1.发明申请CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF 有权抑制VANILLOID受体亚型1（VR1）受体的氯霉素化合物及其用途公开(公告)号：US20110152250A1
公开(公告)日：2011-06-23
申请号：US12875839
申请日：2010-09-03
申请人： Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, JR. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
发明人： Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, JR. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
IPC分类号： A61K31/55 , C07D231/56 , A61K31/416 , C07D215/00 , A61K31/47 , C07D217/00 , C07D401/02 , A61K31/4709 , C07D403/02 , C07D413/02 , A61K31/5377 , A61P29/00 , A61P13/00 , A61P19/02
CPC分类号： C07D405/12 , C07D401/12 , C07D403/12 , C07D413/12
摘要： Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
摘要翻译： 作为VR1受体的拮抗剂的化合物，其具有式（I）或其前药的药学上可接受的盐，前药或盐，其中A1，A2，A3，A4，R7，R8，R9，X，Y，Z， L，n和m如本文所定义，并且可用于通过抑制VR1受体而防止或改善的病症。
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2.发明授权Tetrahydroquinolinyl compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof 有权抑制香草素受体亚型1（VR1）受体的四氢喹啉基化合物及其用途公开(公告)号：US08440691B2
公开(公告)日：2013-05-14
申请号：US12875839
申请日：2010-09-03
申请人： Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, Jr. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
发明人： Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, Jr. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
IPC分类号： A61K31/47 , A61K31/445 , A61K31/415 , C07D217/00 , C07D215/00 , C07D211/00 , C07D231/56
CPC分类号： C07D405/12 , C07D401/12 , C07D403/12 , C07D413/12
摘要： Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
摘要翻译： 作为VR1受体的拮抗剂的化合物，其具有式（I）或其前药的药学上可接受的盐，前药或盐，其中A1，A2，A3，A4，R7，R8，R9，X，Y，Z， L，n和m如本文所定义，并且可用于通过抑制VR1受体而防止或改善的病症。
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3.发明授权Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof 有权抑制香草素受体亚型1（VR1）受体的丝氨酸脲化合物及其用途公开(公告)号：US07812019B2
公开(公告)日：2010-10-12
申请号：US11285448
申请日：2005-11-22
申请人： Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, Jr. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
发明人： Arthur Gomtsyan , Erol K. Bayburt , Robert G. Schmidt, Jr. , Chih-Hung Lee , Brian S. Brown , Tammie K. Jinkerson , John R. Koenig , Jerome F. Daanen , Steven P. Latshaw
IPC分类号： A61K31/5375 , A61K31/47 , A61K31/445 , A61K31/415 , A61K31/35 , C07D413/00 , C07D217/00 , C07D215/00 , C07D211/00 , C07D231/56 , C07D311/00
CPC分类号： C07D405/12 , C07D401/12 , C07D403/12 , C07D413/12
摘要： Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
摘要翻译： 作为VR1受体的拮抗剂的化合物，其具有式（I）或其前药的药学上可接受的盐，前药或盐，其中A1，A2，A3，A4，R7，R8，R9，X，Y，Z， L，n和m如本文所定义，并且可用于通过抑制VR1受体而防止或改善的病症。
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公开(公告)号：US20120022103A1
公开(公告)日：2012-01-26
申请号：US13249010
申请日：2011-09-29
申请人： Erol K. Bayburt , Jerome F. Daanen , Arthur R. Gomtsyan , Steven P. Latshaw , Chih-hung Lee , Robert G. Schmidt, JR.
发明人： Erol K. Bayburt , Jerome F. Daanen , Arthur R. Gomtsyan , Steven P. Latshaw , Chih-hung Lee , Robert G. Schmidt, JR.
IPC分类号： A61K31/353 , C07D311/92 , A61K31/352 , C07D215/46 , A61P13/00 , C07C275/32 , A61K31/17 , A61P25/00 , A61P25/06 , A61P13/10 , C07D311/58 , A61K31/4706
CPC分类号： C07C275/32 , C07D215/12 , C07D215/42 , C07D215/54 , C07D311/58 , C07D311/74
摘要： The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.
摘要翻译： 本申请涉及作为TRPV1拮抗剂并且具有式（I）的化合物，其中变量Ar1，L1，R1，R2，R3，R4，R5，Y1，Y2和Y3如说明书中所定义，它们是有用的 用于治疗由香草素受体活性引起或加剧的病症。
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公开(公告)号：US08030504B2
公开(公告)日：2011-10-04
申请号：US11954875
申请日：2007-12-12
申请人： Erol K. Bayburt , Jerome F. Daanen , Arthur R. Gomtsyan , Steven P. Latshaw , Chih-hung Lee , Robert G. Schmidt, Jr.
发明人： Erol K. Bayburt , Jerome F. Daanen , Arthur R. Gomtsyan , Steven P. Latshaw , Chih-hung Lee , Robert G. Schmidt, Jr.
IPC分类号： C07D311/00
CPC分类号： C07C275/32 , C07D215/12 , C07D215/42 , C07D215/54 , C07D311/58 , C07D311/74
摘要： The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.
摘要翻译： 本申请涉及作为TRPV1拮抗剂并且具有式（I）的化合物，其中变量Ar1，L1，R1，R2，R3，R4，R5，Y1，Y2和Y3如说明书中所定义，它们是有用的 用于治疗由香草素受体活性引起或加剧的病症。
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公开(公告)号：US08350083B2
公开(公告)日：2013-01-08
申请号：US13249010
申请日：2011-09-29
申请人： Arthur R. Gomtsyan , Robert G. Schmidt , Jerome F. Daanen , Erol K. Bayburt , Chih-hung Lee , Steven P. Latshaw
发明人： Arthur R. Gomtsyan , Robert G. Schmidt , Jerome F. Daanen , Erol K. Bayburt , Chih-hung Lee , Steven P. Latshaw
IPC分类号： C07C275/00 , C07D215/44
CPC分类号： C07C275/32 , C07D215/12 , C07D215/42 , C07D215/54 , C07D311/58 , C07D311/74
摘要： The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.
摘要翻译： 本申请涉及作为TRPV1拮抗剂并且具有式（I）的化合物，其中变量Ar1，L1，R1，R2，R3，R4，R5，Y1，Y2和Y3如说明书中所定义，它们是有用的 用于治疗由香草素受体活性引起或加剧的病症。
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公开(公告)号：US20080153871A1
公开(公告)日：2008-06-26
申请号：US11954875
申请日：2007-12-12
申请人： Erol K. Bayburt , Jerome F. Daanen , Arthur R. Gomtsyan , Steven P. Latshaw , Chih-hung Lee , Robert G. Schmidt
发明人： Erol K. Bayburt , Jerome F. Daanen , Arthur R. Gomtsyan , Steven P. Latshaw , Chih-hung Lee , Robert G. Schmidt
IPC分类号： A61K31/47 , C07D311/04 , C07D215/00 , A61K31/17 , A61P13/02 , A61P43/00 , C07C275/00 , A61K31/352
CPC分类号： C07C275/32 , C07D215/12 , C07D215/42 , C07D215/54 , C07D311/58 , C07D311/74
摘要： The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.
摘要翻译： 本申请涉及作为TRPV1拮抗剂并且具有式（I）的化合物，其中变量Ar 1，L 1，R 1，R 1， R 3，R 3，R 4，R 5，Y 1，Y 3， 描述中定义的那些，其可用于治疗由香草素受体活性引起或加剧的病症。
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公开(公告)号：US20090105306A1
公开(公告)日：2009-04-23
申请号：US12246808
申请日：2008-10-07
申请人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
发明人： William A. Carroll , Michael J. Dart , Arturo Perez-Medrano , Derek W. Nelson , Tongmei Li , Sridhar Peddi , Jennifer Frost , Teodozyj Kolasa , Bo Liu , Steven P. Latshaw , Xueqing Wang
IPC分类号： A61K31/433 , C07D417/02 , C07D285/12 , C07D405/02 , C07D413/02 , A61P29/00 , A61P9/00 , A61P35/00 , A61P37/00 , A61P25/00 , A61K31/443 , A61K31/422 , A61K31/4155
CPC分类号： C07D405/06 , C07D405/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/14
摘要： The present invention relates compounds of formula (I) wherein A and R1 are as defined in the specification, pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions.
摘要翻译： 本发明涉及式（I）的化合物，其中A和R 1如说明书中所定义，包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。
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公开(公告)号：US20090247500A1
公开(公告)日：2009-10-01
申请号：US12401788
申请日：2009-03-11
申请人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez Medrano , Xueqing Wang , Karin Rosemarie Tietje , Sridhar Peddi , William A. Carroll
发明人： Teodozyj Kolasa , Jennifer M. Frost , Meena V. Patel , Steven P. Latshaw , Arturo Perez Medrano , Xueqing Wang , Karin Rosemarie Tietje , Sridhar Peddi , William A. Carroll
IPC分类号： A61K31/427 , C07D417/02 , C07D417/14 , A61P25/00 , A61P11/00 , A61P9/00 , A61K31/4439 , A61K31/454
CPC分类号： C07D417/06
摘要： Disclosed herein are compounds of formula (I) wherein R1, R2, R3, R25a, R26a, X, and n are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions are also described.
摘要翻译： 本文公开了式（I）的化合物，其中R 1，R 2，R 3，R 25a，R 26a，X和n如说明书中所定义。 还描述了包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和病症的方法。
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10.发明授权Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction 有权用于治疗性功能障碍的稠合双环芳香化合物公开(公告)号：US07235661B2
公开(公告)日：2007-06-26
申请号：US11395807
申请日：2006-03-31
IPC分类号： C07D495/04 , C07D513/04 , A61K31/496 , A61K31/506
CPC分类号： A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/495 , A61K31/496 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1, are as described in the specification.
摘要翻译： 本发明涉及式（I）化合物用于治疗性功能障碍的用途和含有式（I）化合物用于治疗性功能障碍的组合物的用途，其中A，L，D和B < / SUB>，如说明书中所述。
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