中科微点-全球专利检索

  1. Login
  2. Sign Up
Invention Grant
US08124756B2 Method of preparing 5′-amino-linker oligonucleotides derivatives and analogous 5′-labeled-linker oligonucleotides therefrom 有权
从其中制备5'-氨基 - 连接寡核苷酸衍生物和类似的5'-标记 - 接头寡核苷酸的方法

Method of preparing 5′-amino-linker oligonucleotides derivatives and analogous 5′-labeled-linker oligonucleotides therefrom
Abstract:
A method for preparing amino linker oligonucleotides is provided. More specifically, a method of preparing 5′-amino-linker oligonucleotides comprising the steps of: introducing an amino linker having a protecting group into the 5′ terminus of an oligonucleotide; and removing the protecting group from the amino linker oligonucleotide by contacting with acetic acid and 2,2,2-trifluoroethanol is provided. The amino protecting group is efficiently removed from the amino linker oligonucleotides, and thereby achieving a high yield of the amino linker oligonucleotides.
Abstract(Chinese):

提供了制备氨基接头寡核苷酸的方法。 更具体地说，制备5'-氨基连接寡核苷酸的方法包括以下步骤：将具有保护基的氨基接头引入寡核苷酸的5'末端; 并通过与乙酸和2,2,2-三氟乙醇接触，从氨基接头寡核苷酸中除去保护基。 从氨基接头寡核苷酸有效地除去氨基保护基，从而达到高产量的氨基接头寡核苷酸。

Public/Granted literature
Information query
Espacenet
Patent Agency Ranking
0/0