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1.发明授权Method of preparing 5′-amino-linker oligonucleotides derivatives and analogous 5′-labeled-linker oligonucleotides therefrom 有权从其中制备5'-氨基 - 连接寡核苷酸衍生物和类似的5'-标记 - 接头寡核苷酸的方法公开(公告)号：US08124756B2
公开(公告)日：2012-02-28
申请号：US12559666
申请日：2009-09-15
申请人： Jung-Hwan Lee , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang
发明人： Jung-Hwan Lee , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang
IPC分类号： C07H21/00
摘要： A method for preparing amino linker oligonucleotides is provided. More specifically, a method of preparing 5′-amino-linker oligonucleotides comprising the steps of: introducing an amino linker having a protecting group into the 5′ terminus of an oligonucleotide; and removing the protecting group from the amino linker oligonucleotide by contacting with acetic acid and 2,2,2-trifluoroethanol is provided. The amino protecting group is efficiently removed from the amino linker oligonucleotides, and thereby achieving a high yield of the amino linker oligonucleotides.
摘要翻译： 提供了制备氨基接头寡核苷酸的方法。 更具体地说，制备5'-氨基连接寡核苷酸的方法包括以下步骤：将具有保护基的氨基接头引入寡核苷酸的5'末端; 并通过与乙酸和2,2,2-三氟乙醇接触，从氨基接头寡核苷酸中除去保护基。 从氨基接头寡核苷酸有效地除去氨基保护基，从而达到高产量的氨基接头寡核苷酸。
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公开(公告)号：US08569252B2
公开(公告)日：2013-10-29
申请号：US12759813
申请日：2010-04-14
申请人： Jung-Hwan Lee , Soon-Hag Kim , Mi-Jin Kwon , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Youn-Dong Kim , Young-Chan Chae , Sung-Key Jang , Jong-Hun Im , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang , Ki-Seok Kim
发明人： Jung-Hwan Lee , Soon-Hag Kim , Mi-Jin Kwon , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Youn-Dong Kim , Young-Chan Chae , Sung-Key Jang , Jong-Hun Im , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang , Ki-Seok Kim
IPC分类号： C12N15/11
CPC分类号： G01N33/57496 , C12N15/115 , C12N2310/16 , C12N2310/335
摘要： Improved G-rich oligonucleotide (GRO) aptamers specific to nucleolin, a method of preparing the aptamers, and a use of the aptamers for diagnosing and/or treating a nucleolin-associated disease, are provided.
摘要翻译： 提供了改进的对核仁林特异性的富G寡核苷酸（GRO）适配体，制备适体的方法，以及适配体用于诊断和/或治疗核仁素相关疾病的用途。
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3.发明申请REPARATION METHOD OF AN AMINO LINKER OLIGONUCLEOTIDES AND LABELED-LINKER OLIGONUCLEOTIDE THEREFROM 有权氨基连接子寡核苷酸和标记的寡核苷酸寡核苷酸的重复方法公开(公告)号：US20100093994A1
公开(公告)日：2010-04-15
申请号：US12559666
申请日：2009-09-15
申请人： Jung-Hwan LEE , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang
发明人： Jung-Hwan LEE , Hyun-Gu Kang , Sung-Ho Ryu , Jong-In Kim , Sun-Hak Lee , Hye-Jung Lee , Eun-Jung Jang
IPC分类号： C08B37/00
摘要： A method for preparing amino linker oligonucleotides is provided, wherein an amino protecting group is efficiently removed from the amino linker oligonucleotides protected by the protecting group, and thereby achieving a high yield of the amino linker oligonucleotides.
摘要翻译： 提供了制备氨基接头寡核苷酸的方法，其中氨基保护基被有效地从保护基保护的氨基接头寡核苷酸中除去，从而达到高产量的氨基接头寡核苷酸。
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公开(公告)号：US20110111477A9
公开(公告)日：2011-05-12
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： C12N9/00 , C07D207/40 , C07K14/00 , C07H21/00 , C07H1/00
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译： 本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。 通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。
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公开(公告)号：US08247493B2
公开(公告)日：2012-08-21
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang Hahn , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang Hahn , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： A61K47/48
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译： 本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。 通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。
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公开(公告)号：US20100261245A1
公开(公告)日：2010-10-14
申请号：US12422950
申请日：2009-04-13
申请人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
发明人： Sei-Kwang HAHN , Hyun-Gu Kang , Sung-Ho Ryu , Jung-Kyu Park , Eun-Ju Oh
IPC分类号： C12N9/00 , C07D207/40 , C07K14/00 , C07H21/00 , C07H1/00
CPC分类号： C08G65/329 , A61K47/60 , C08G65/33337 , C08G65/33396 , C08L2203/02
摘要： The invention relates to a long-acting formulation of biopharmaceutical, more specifically an aptamer therapeutics. A branched PEGylated aptamer or a hyaluronic acid (HA) derivative of which degradation in vivo is regulated is linked by the bioconjugation with biopharmaceutical to produce the long-action formulation.
摘要翻译： 本发明涉及生物药剂的长效制剂，更具体地涉及适体治疗剂。 通过与生物药物的生物缀合来连接体内降解调节的支化聚乙二醇化适体或透明质酸（HA）衍生物，以产生长效制剂。
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公开(公告)号：US20100328961A1
公开(公告)日：2010-12-30
申请号：US12703279
申请日：2010-02-10
申请人： You-Jin KWON , Won-Il Kim , Hyun-Gu Kang , Seung-Ryeol Ryu , Sang-Geun Bae , Seung-Sik Hong
发明人： You-Jin KWON , Won-Il Kim , Hyun-Gu Kang , Seung-Ryeol Ryu , Sang-Geun Bae , Seung-Sik Hong
CPC分类号： F21V19/001 , F21V19/045 , F21Y2115/10 , H01L33/486 , H01L2224/48091 , H01L2224/48227 , H05K3/301 , H05K2201/10106 , H05K2201/1059 , H05K2201/10598 , H01L2924/00014
摘要： A light-emitting module includes a printed circuit board (PCB), a fastening member, and a light-emitting package. The PCB has a power-supplying pad to provide electrical power. The fastening member is disposed on the PCB and has a package-receiving hole exposing the power-supplying pad. The light-emitting package is received by the package-receiving hole such that the light-emitting package is electrically connected to the power-supplying pad and detachably coupled with the fastening member. Therefore, the light-emitting package may be easily combined with the PCB, and the light-emitting package may be replaced when desired.
摘要翻译： 发光模块包括印刷电路板（PCB），紧固构件和发光封装。 PCB具有供电电源以提供电力。 紧固构件设置在PCB上并且具有暴露供电垫的封装容纳孔。 发光封装由封装容纳孔接收，使得发光封装电连接到供电焊盘并且可拆卸地与紧固构件连接。 因此，发光封装可以容易地与PCB组合，并且如果需要，可以更换发光封装。
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公开(公告)号：US09145243B2
公开(公告)日：2015-09-29
申请号：US14074094
申请日：2013-11-07
申请人： Yoo-Ra Kim , Hyun-Gu Kang , Jae-Moon Kim , Su-Yeon Yun
发明人： Yoo-Ra Kim , Hyun-Gu Kang , Jae-Moon Kim , Su-Yeon Yun
CPC分类号： B65D51/245 , A47G19/2227 , A47G2019/2238 , G09G3/3225 , G09G2300/0443 , G09G2320/041 , G09G2320/0626 , G09G2340/14 , H01L27/326
摘要： Provided is a cup to which a transparent display is applied, the cup including a body comprising a display unit capable of showing contents in the body or displaying content; and a support being attached to or detached from the body, generating a control signal so as to control the content displayed on the display unit, and transmitting the control signal to the body.
摘要翻译： 提供了一种应用透明显示器的杯子，杯子包括：主体，其包括能够显示身体内容物或显示内容的显示单元; 以及支撑件附接到身体或从主体分离，产生控制信号以便控制显示在显示单元上的内容，并将控制信号发送到身体。
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9.发明授权Nucleic acid delivery system comprising conjugates of PEI and hyaluronic acid 有权包含PEI和透明质酸的缀合物的核酸递送系统公开(公告)号：US08318856B2
公开(公告)日：2012-11-27
申请号：US12733061
申请日：2008-04-04
申请人： Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , Ii-Hwan Cho , Sei-Kwang Hahn
发明人： Yu-Kyoung Oh , Hyun-Gu Kang , Ji-Seok Kim , Jiang Ge , Ki-Su Kim , Ki-Tae Park , Su-Eun Han , Ga-Yong Shim , Ii-Hwan Cho , Sei-Kwang Hahn
摘要： The present invention relates to a delivery system for nucleic acid using a cationic polymer conjugate, and more specifically relates to a delivery system for nucleic acid comprising a cationic polymer conjugate prepared by conjugating hyaluronic acid or its derivative and polyethyleneimine, and a composition of delivering a nucleic acid into mammalian cell comprising a complex of the nucleic acid and a cationic polymer conjugate with electrostatic binding.
摘要翻译： 本发明涉及使用阳离子聚合物缀合物的核酸递送系统，并且更具体地涉及用于核酸的递送系统，其包含通过将透明质酸或其衍生物和聚乙烯亚胺缀合而制备的阳离子聚合物缀合物，以及递送 核酸进入哺乳动物细胞，其包含核酸和具有静电结合的阳离子聚合物缀合物的复合物。
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公开(公告)号：US08192068B2
公开(公告)日：2012-06-05
申请号：US12703279
申请日：2010-02-10
申请人： You-Jin Kwon , Won-Il Kim , Hyun-Gu Kang , Seung-Ryeol Ryu , Sang-Geun Bae , Seung-Sik Hong
发明人： You-Jin Kwon , Won-Il Kim , Hyun-Gu Kang , Seung-Ryeol Ryu , Sang-Geun Bae , Seung-Sik Hong
CPC分类号： F21V19/001 , F21V19/045 , F21Y2115/10 , H01L33/486 , H01L2224/48091 , H01L2224/48227 , H05K3/301 , H05K2201/10106 , H05K2201/1059 , H05K2201/10598 , H01L2924/00014
摘要： A light-emitting module includes a printed circuit board (PCB), a fastening member, and a light-emitting package. The PCB has a power-supplying pad to provide electrical power. The fastening member is disposed on the PCB and has a package-receiving hole exposing the power-supplying pad. The light-emitting package is received by the package-receiving hole such that the light-emitting package is electrically connected to the power-supplying pad and detachably coupled with the fastening member. Therefore, the light-emitting package may be easily combined with the PCB, and the light-emitting package may be replaced when desired.
摘要翻译： 发光模块包括印刷电路板（PCB），紧固构件和发光封装。 PCB具有供电电源以提供电力。 紧固构件设置在PCB上并且具有暴露供电垫的封装容纳孔。 发光封装由封装容纳孔接收，使得发光封装电连接到供电焊盘并且可拆卸地与紧固构件连接。 因此，发光封装可以容易地与PCB组合，并且如果需要，可以更换发光封装。
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