Invention Grant
- Patent Title: Reduced by-product accumulation for improved production of isobutanol
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Application No.: US13074907Application Date: 2011-03-29
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Publication No.: US08133715B2Publication Date: 2012-03-13
- Inventor: Thomas Buelter , Andrew Hawkins , Stephanie Porter-Scheinman , Peter Meinhold , Catherine Asleson Dundon , Aristos Aristidou , Jun Urano , Matthew Peters , Melissa Dey , Justas Jancauskas , Julie Kelly , Ruth Berry
- Applicant: Thomas Buelter , Andrew Hawkins , Stephanie Porter-Scheinman , Peter Meinhold , Catherine Asleson Dundon , Aristos Aristidou , Jun Urano , Matthew Peters , Melissa Dey , Justas Jancauskas , Julie Kelly , Ruth Berry
- Applicant Address: US CO Englewood
- Assignee: Gevo, Inc.
- Current Assignee: Gevo, Inc.
- Current Assignee Address: US CO Englewood
- Agency: Cooley LLP
- Main IPC: C12N1/00
- IPC: C12N1/00 ; C12N15/00 ; C12N15/87 ; C12N15/74 ; C12P7/16 ; C12P1/00 ; C07H21/04 ; C07K1/00
Abstract:
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
Public/Granted literature
- US20110275129A1 Reduced by-product accumulation for improved production of isobutanol Public/Granted day:2011-11-10
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