Invention Grant
US08148105B2 Scaleable manufacturing process for cysteine endoprotease B, isoform 2
失效
半胱氨酸内切蛋白酶B，同工型2的可扩展制造方法
- Patent Title: Scaleable manufacturing process for cysteine endoprotease B, isoform 2
- Patent Title (中): 半胱氨酸内切蛋白酶B，同工型2的可扩展制造方法
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Application No.: US12531037Application Date: 2008-03-14
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Publication No.: US08148105B2Publication Date: 2012-04-03
- Inventor: Harmit Vora , James McIntire , Pawan Kumar , Chaitan Khosla
- Applicant: Harmit Vora , James McIntire , Pawan Kumar , Chaitan Khosla
- Applicant Address: US CA Palo Alto US CA San Carlos
- Assignee: The Board of Trustees of the Leland Stanford Junior University,Alvine Pharmaceuticals, Inc.
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University,Alvine Pharmaceuticals, Inc.
- Current Assignee Address: US CA Palo Alto US CA San Carlos
- Agency: Bozicevic, Field & Francis LLP
- Agent Pamela J. Sherwood
- International Application: PCT/US2008/003425 WO 20080314
- International Announcement: WO2008/115428 WO 20080925
- Main IPC: C12N15/09
- IPC: C12N15/09 ; C12N15/29 ; C12N15/57 ; C12N9/50 ; C07K1/14 ; C07K1/22
Abstract:
Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and purification processes, which processes may be combined with lyophilization to yield a stable product.
Public/Granted literature
- US20100196955A1 Scaleable Manufacturing Process for Cysteine Endoprotease B, Isoform 2 Public/Granted day:2010-08-05
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