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US08337704B2 Manipulation of magnetic microparticles in a high pressure liquid system and extraction process 有权
在高压液体系统中操作磁性微粒和萃取过程

Manipulation of magnetic microparticles in a high pressure liquid system and extraction process
Abstract:
The invention concerns a device and a method for the manipulation of a liquid sample material in which magnetic microparticles are suspended whereby the microparticles have a functionalized surface and an analyte is bound to the surface. The sample material is introduced into a device with a liquid system through an injection device (50) and in a first mobile phase the sample material is carried to an extractor (90). In a first section (97a) of the extractor (90) the microparticles are immobilized by means of a magnetic field of a controllable device (96) and separated from the remaining sample material. By switching over of a switching unit (110) a second mobile phase (75) is carried to the extractor (90) and the second mobile phase (75) detaches the adsorbed analyte from the surface of the microparticles. In a second section (97b) of the extractor (90) the microparticles are immobilized and the second mobile phase (75) with the dissolved analyte(s) can be analyzed by way of chromatographic separation (130) and subsequent detection (140).
Abstract(Chinese):

本发明涉及用于操纵其中悬浮磁性微粒的液体样品材料的装置和方法，由此微粒具有官能化表面并且分析物结合到表面。 将样品材料通过注射装置（50）引入具有液体系统的装置中，并且在第一流动相中将样品材料运送到提取器（90）。 在提取器（90）的第一部分（97a）中，微粒通过可控设备（96）的磁场被固定，并与剩余的样品材料分离。 通过切换开关单元（110），将第二流动相（75）运送到提取器（90），并且第二流动相（75）将吸附的分析物从微粒表面分离。 在提取器（90）的第二部分（97b）中，微粒被固定，并且可以通过色谱分离（130）和随后的检测（140）分析具有溶解的分析物的第二流动相（75）。

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