Invention Grant
- Patent Title: Method for treatment of bronchial asthma
- Patent Title (中): 治疗支气管哮喘的方法
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Application No.: US13365979Application Date: 2012-02-03
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Publication No.: US08519154B2Publication Date: 2013-08-27
- Inventor: Sibabrata Mukhopadhyay , Mumu Chakraborty , Tulika Mukherjee , Arun Bandyopadhyay , Dipak Kar , Tanima Banerjee , Aditya Konar , Debaprasad Jana , Siddhartha Roy , Santu Bandyopadhyay , Balram Ghosh , Mabalirajan Ulaganathan , Rakesh Kamal Johri , Subhash Chander Sharma , Gurdarshan Singh , Bholanath Paul , Vasanta Madhava Sharma Gangavaram , Jhillu Singh Yadav , Radha Krishna Palakodety
- Applicant: Sibabrata Mukhopadhyay , Mumu Chakraborty , Tulika Mukherjee , Arun Bandyopadhyay , Dipak Kar , Tanima Banerjee , Aditya Konar , Debaprasad Jana , Siddhartha Roy , Santu Bandyopadhyay , Balram Ghosh , Mabalirajan Ulaganathan , Rakesh Kamal Johri , Subhash Chander Sharma , Gurdarshan Singh , Bholanath Paul , Vasanta Madhava Sharma Gangavaram , Jhillu Singh Yadav , Radha Krishna Palakodety
- Applicant Address: IN New Delhi
- Assignee: Council of Scientific & Industrial Research
- Current Assignee: Council of Scientific & Industrial Research
- Current Assignee Address: IN New Delhi
- Agency: Sughrue Mion, PLLC
- Priority: IN267/DEL/2011 20110204
- Main IPC: C07D209/82
- IPC: C07D209/82 ; C07D209/88 ; A61K31/403
Abstract:
The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthma and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients.Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below: wherein R1=H or OCH3; R2═CH3 or CHO; R3═H or OCH3; R4═H or OCH3 Herbal route for the isolation of compound of general formula 1 from the bark of plant Murraya Koenigii and chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.
Public/Granted literature
- US20120202868A1 METHOD FOR TREATMENT OF BRONCHIAL ASTHMA Public/Granted day:2012-08-09
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