公开(公告)号：US08519154B2

公开(公告)日：2013-08-27

申请号：US13365979

申请日：2012-02-03

申请人： Sibabrata Mukhopadhyay ,  Mumu Chakraborty ,  Tulika Mukherjee ,  Arun Bandyopadhyay ,  Dipak Kar ,  Tanima Banerjee ,  Aditya Konar ,  Debaprasad Jana ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Balram Ghosh ,  Mabalirajan Ulaganathan ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Gurdarshan Singh ,  Bholanath Paul ,  Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety

发明人： Sibabrata Mukhopadhyay ,  Mumu Chakraborty ,  Tulika Mukherjee ,  Arun Bandyopadhyay ,  Dipak Kar ,  Tanima Banerjee ,  Aditya Konar ,  Debaprasad Jana ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Balram Ghosh ,  Mabalirajan Ulaganathan ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Gurdarshan Singh ,  Bholanath Paul ,  Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety

IPC分类号： C07D209/82 ,  C07D209/88 ,  A61K31/403

CPC分类号： C07D209/86 ,  A61K31/404

摘要： The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthma and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients.Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below: wherein R1=H or OCH3; R2═CH3 or CHO; R3═H or OCH3; R4═H or OCH3 Herbal route for the isolation of compound of general formula 1 from the bark of plant Murraya Koenigii and chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.

摘要翻译： 本发明涉及一种治疗支气管哮喘和慢性阻塞性肺疾病（COPD）的方法，其包括向患有哮喘和COPD的患者施用有效剂量的咔唑衍生物或其盐，任选地与药学上可接受的赋形剂。 用作磷酸二酯酶-4（PDE-4）酶抑制剂的通式1化合物的结构式，用于治疗哮喘和哮喘相关疾病的信号分子抑制剂如下：其中R1 = H或OCH3; R2 = CH3或CHO; R3 = H或OCH3; R4 = H或OCH3用于从植物Murraya Koenigii的树皮中分离通式1的化合物的草药路线以及用于从碱性化合物如香草醛制备这些化合物的化学途径也被报道。

公开(公告)号：US20120283263A1

公开(公告)日：2012-11-08

申请号：US13321445

申请日：2010-12-31

申请人： Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

发明人： Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

IPC分类号： A61K31/53 ,  A61P11/06 ,  C12Q1/18 ,  C07D403/14

CPC分类号： C07D403/14 ,  A61K31/53 ,  C07D251/50 ,  C07D251/52

摘要： A novel heterocyclic compound belonging to ‘triazine-aryl-bis-indoles’, useful for the treatment of asthma. The pathway by which this compound inhibits asthma is also demonstrated. The present invention also provides a process for the preparation of above compounds and their derivatives are presented.

摘要翻译： 属于三嗪 - 芳基 - 双 - 吲哚的新型杂环化合物，可用于治疗哮喘。 还证明了该化合物抑制哮喘的途径。 本发明还提供了制备上述化合物的方法及其衍生物。

公开(公告)号：US09085559B2

公开(公告)日：2015-07-21

申请号：US13321445

申请日：2010-12-31

申请人： Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

发明人： Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

IPC分类号： C07D403/14 ,  C07D251/50 ,  C07D251/52 ,  A61K31/53 ,  A61P11/06

CPC分类号： C07D403/14 ,  A61K31/53 ,  C07D251/50 ,  C07D251/52

摘要： A novel heterocyclic compound belonging to ‘triazine-aryl-bis-indoles’, useful for the treatment of asthma. The pathway by which this compound inhibits asthma is also demonstrated. The present invention also provides a process for the preparation of above compounds and their derivatives are presented.

摘要翻译： 属于“三嗪 - 芳基 - 双 - 吲哚”的新型杂环化合物，可用于治疗哮喘。 还证明了该化合物抑制哮喘的途径。 本发明还提供了制备上述化合物的方法及其衍生物。

公开(公告)号：US08580752B2

公开(公告)日：2013-11-12

申请号：US11391391

申请日：2006-03-29

申请人： Surrinder Koul ,  Jawahir Lal Koul ,  Subhash Chandra Taneja ,  Pankaj Gupta ,  Inshad Ali Khan ,  Zahid Mehmood Mirza ,  Ashwani Kumar ,  Rakesh Kamal Johri ,  Monika Pandita ,  Anita Khosa ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Vijeshwar Verma ,  Ghulam Nabi Qazi

发明人： Surrinder Koul ,  Jawahir Lal Koul ,  Subhash Chandra Taneja ,  Pankaj Gupta ,  Inshad Ali Khan ,  Zahid Mehmood Mirza ,  Ashwani Kumar ,  Rakesh Kamal Johri ,  Monika Pandita ,  Anita Khosa ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Vijeshwar Verma ,  Ghulam Nabi Qazi

IPC分类号： A61K31/70

CPC分类号： C07D211/46 ,  A61K31/351 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/453 ,  A61K31/496 ,  A61K31/7036 ,  C07D295/108 ,  C07D311/58 ,  C07D317/60 ,  C07D319/16 ,  C07D319/18 ,  Y02A50/473 ,  Y02A50/481

摘要： The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

摘要翻译： 本发明涉及芳族取代的戊二烯酸酰胺，并且其中使用特定量的芳族酰胺，即4-烷基-5-（取代的苯基）-2（E），4（E） - 戊二烯酸酰胺，其几何形状 异构体或其二氢或四氢衍生物和用于增强抗感染药物生物功效的抗感染药物。 本发明的组合可用于治疗抑制微生物菌株生长所必需的较低浓度抗感染剂的某些感染和疾病，并且还可用于降低微生物的抗性。

公开(公告)号：US07119075B2

公开(公告)日：2006-10-10

申请号：US10404014

申请日：2003-03-31

申请人： Ghulam Nabi Qazi ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Inshad Ali Khan ,  Vijeshwar Verma ,  Rakesh Kamal Johri ,  Krishan Avtar Suri ,  Bishan Datt Gupta ,  Naresh Kumar Satti ,  Manoj Kumar Tikoo ,  Subhash Chander Sharma ,  Ashok Kumar Tikoo

发明人： Ghulam Nabi Qazi ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Inshad Ali Khan ,  Vijeshwar Verma ,  Rakesh Kamal Johri ,  Krishan Avtar Suri ,  Bishan Datt Gupta ,  Naresh Kumar Satti ,  Manoj Kumar Tikoo ,  Subhash Chander Sharma ,  Ashok Kumar Tikoo

IPC分类号： A61K31/70

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/4525 ,  A61K31/455 ,  A61K31/7048 ,  A61K2300/00

摘要： The present invention relates to the use of bioenhancers to decrease the resistance of microbial strains to anti-infective such an antibiotics and antifungals by potentiating the activities of anti-infective. This may be useful to reduce resistance in bacteria and yeast to aid in the treatment of certain infections and disease and to lower the concentration of antiinfectives necessary to inhibit the growth of microbial strains.

摘要翻译： 本发明涉及通过增强抗感染活性来降低微生物菌株对抗感染性抗生素和抗真菌剂的抗性的用途。 这可能有助于降低细菌和酵母中的抗性，以帮助治疗某些感染和疾病，并降低抑制微生物菌株生长所必需的抗感染药物的浓度。

公开(公告)号：US07514105B2

公开(公告)日：2009-04-07

申请号：US11360653

申请日：2006-02-23

申请人： Ghulam Nabi Qazi ,  Kasturi Lal Bedi ,  Rakesh Kamal Johri ,  Manoj Kumar Tikoo ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Sheikh Tasaduq Abdullah ,  Om Parkash Suri ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Ravi Kant Khajuria ,  Surjit Singh ,  Anamika Khajuria ,  Bal Krishan Kapahi

发明人： Ghulam Nabi Qazi ,  Kasturi Lal Bedi ,  Rakesh Kamal Johri ,  Manoj Kumar Tikoo ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Sheikh Tasaduq Abdullah ,  Om Parkash Suri ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Ravi Kant Khajuria ,  Surjit Singh ,  Anamika Khajuria ,  Bal Krishan Kapahi

IPC分类号： A61K36/00 ,  A61K36/752

CPC分类号： A61K45/06 ,  A23L33/105 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A61K31/43 ,  A61K31/4453 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/545 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/04 ,  A61K36/185 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/47 ,  A61K36/59 ,  A61K36/67 ,  A61K36/75 ,  A61K36/80 ,  A61K36/81 ,  A61K36/8965 ,  A61K2300/00

摘要： The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising: an effective amount of an extract and/or at least one bioactive fraction from Cuminum cyminum; one or more additive selected from drugs, nutrients, vitamins, nutraceuticals, herbal drugs/products, micro nutrients, antioxidants along with pharmaceuticaly acceptable additives/excipient, and optionally, an effective amount of piperine or extract/fraction of piper nigrum or piper longum; and a process for the preparation of such extracts and active fractions from plant Cuminum cyminum.

摘要翻译： 本发明涉及生物增强/生物利用度促进组合物，其包含：有效量的来自孜然的提取物和/或至少一种生物活性级分; 一种或多种选自药物，营养素，维生素，营养品，草药/产品，微量营养素，抗氧化剂以及药用可接受的添加剂/赋形剂的添加剂，以及任选的有效量的胡椒碱或胡椒或胡椒的提取物/级分; 以及从植物孜然中制备这些提取物和活性级分的方法。

公开(公告)号：US07070814B2

公开(公告)日：2006-07-04

申请号：US10386395

申请日：2003-03-11

申请人： Ghulam Nabi Qazi ,  Kasturi Lal Bedi ,  Rakesh Kamal Johri ,  Manoj Kumar Tikoo ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Sheikh Tasaduq Absullah ,  Om Parkash Suri ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Ravi Kant Khajuria ,  Surjit Singh ,  Anamika Khajuria ,  Bal Krishan Kapahi

发明人： Ghulam Nabi Qazi ,  Kasturi Lal Bedi ,  Rakesh Kamal Johri ,  Manoj Kumar Tikoo ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Sheikh Tasaduq Absullah ,  Om Parkash Suri ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Ravi Kant Khajuria ,  Surjit Singh ,  Anamika Khajuria ,  Bal Krishan Kapahi

IPC分类号： A61K35/78

CPC分类号： A61K45/06 ,  A23L33/105 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A61K31/43 ,  A61K31/4453 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/545 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/04 ,  A61K36/185 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/47 ,  A61K36/59 ,  A61K36/67 ,  A61K36/75 ,  A61K36/80 ,  A61K36/81 ,  A61K36/8965 ,  A61K2300/00

摘要： The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising: an effective amount of an extract and/or at least one bioactive fraction from Cuminum cyminum; one or more additive selected from drugs, nutrients, vitamins, nutraceuticals, herbal drugs/products, micro nutrients, antioxidants along with pharmaceutically acceptable additives/excipient, and optionally, an effective amount of piperine or extract/fraction of piper nigrum or piper longum; and a process for the preparation of such extracts and active fractions from plant Cuminum cyminum.

摘要翻译： 本发明涉及生物增强/生物利用度促进组合物，其包含：有效量的来自孜然的提取物和/或至少一种生物活性级分; 一种或多种选自药物，营养素，维生素，营养品，草药/产品，微量营养素，抗氧化剂以及药学上可接受的添加剂/赋形剂的添加剂，以及任选的有效量的胡椒碱或胡椒或胡椒的提取物/级分; 以及从植物孜然中制备这些提取物和活性级分的方法。

公开(公告)号：US20080292736A1

公开(公告)日：2008-11-27

申请号：US12011582

申请日：2008-01-28

申请人： Ghulam Nabi Qazi ,  Kasturi Lal Bedi ,  Rakesh Kamal Johri ,  Manoj Kumar Tikoo ,  Ashok Kumar Tikoo ,  Subhash Chandra Sharma ,  Tasaduaq Abdullah ,  Om Parkash Suri ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Ravi Kant Khajuria

发明人： Ghulam Nabi Qazi ,  Kasturi Lal Bedi ,  Rakesh Kamal Johri ,  Manoj Kumar Tikoo ,  Ashok Kumar Tikoo ,  Subhash Chandra Sharma ,  Tasaduaq Abdullah ,  Om Parkash Suri ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Ravi Kant Khajuria

IPC分类号： A61K36/23 ,  A61K36/9068

CPC分类号： A61K31/7048 ,  A61K31/496 ,  A61K31/497 ,  A61K36/23 ,  A61K36/67 ,  A61K36/9068 ,  A61K2300/00

摘要： The present invention relates to the use of extracts of Carum carvi as bioenhancers, either alone or in combination with piperine or Zingiber officinale extract to improve the bioavailability of a wide variety of drugs.

摘要翻译： 本发明涉及Carum carvi的提取物作为生物降解剂，单独使用或与胡椒碱或姜黄素提取物组合以提高各种药物的生物利用度。

公开(公告)号：US20080138452A1

公开(公告)日：2008-06-12

申请号：US12004403

申请日：2007-12-21

申请人： Rakesh Kamal Johri ,  Sheikh Tasaduq Abdullah ,  Kuldeep Singh ,  Devinder Kumar Gupta ,  Bal Krishan Kapahi ,  Dilip Manikrao Mondhe ,  Satinder Mohan Jain ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Ghulam Nabi Qazi

发明人： Rakesh Kamal Johri ,  Sheikh Tasaduq Abdullah ,  Kuldeep Singh ,  Devinder Kumar Gupta ,  Bal Krishan Kapahi ,  Dilip Manikrao Mondhe ,  Satinder Mohan Jain ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Ghulam Nabi Qazi

IPC分类号： A61K36/47 ,  A61P43/00

CPC分类号： A61K36/47 ,  A61K2300/00

摘要： The present invention relates to a composition useful for hepatocurative effect against CYP 450 bio-activation hepatotoxicity induced by drugs, said composition comprising an extract from Emblica officinalis and optionally pharmaceutically acceptable additives and method of treating drug induced hepatotoxicity

摘要翻译： 本发明涉及一种可用于对由药物诱导的CYP 450生物活化肝毒性的肝脏作用的组合物，所述组合物包含来自Emblica officinalis的提取物和任选的药学上可接受的添加剂和治疗药物诱导的肝毒性的方法

公开(公告)号：US07001619B2

公开(公告)日：2006-02-21

申请号：US10106119

申请日：2002-03-27

申请人： Rakesh Kamal Johri ,  Sheikh Tasaduq Abdullah ,  Kuldeep Singh ,  Devinder Kumar Gupta ,  Bal Krishan Kapahi ,  Dilip Manikrao Mondhe ,  Satinder Mohan Jain ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Ghulam Nabi Qazi

发明人： Rakesh Kamal Johri ,  Sheikh Tasaduq Abdullah ,  Kuldeep Singh ,  Devinder Kumar Gupta ,  Bal Krishan Kapahi ,  Dilip Manikrao Mondhe ,  Satinder Mohan Jain ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Ghulam Nabi Qazi

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K35/00 ,  A61K35/78

CPC分类号： A61K36/47 ,  A61K2300/00

摘要： The present invention relates to a composition useful for hepatocurative effect against CYP 450 bio-activation hepatotoxicity induced by drugs, said composition comprising an extract from Emblica officinalis and optionally pharmaceutically acceptable additives and method of treating drug induced hepatotoxicity.

摘要翻译： 本发明涉及一种可用于对由药物诱导的CYP 450生物活化肝毒性的肝脏作用的组合物，所述组合物包含来自Emblica officinalis的提取物和任选的药学上可接受的添加剂和治疗药物诱导的肝毒性的方法。