公开(公告)号：US08519154B2

公开(公告)日：2013-08-27

申请号：US13365979

申请日：2012-02-03

申请人： Sibabrata Mukhopadhyay ,  Mumu Chakraborty ,  Tulika Mukherjee ,  Arun Bandyopadhyay ,  Dipak Kar ,  Tanima Banerjee ,  Aditya Konar ,  Debaprasad Jana ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Balram Ghosh ,  Mabalirajan Ulaganathan ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Gurdarshan Singh ,  Bholanath Paul ,  Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety

发明人： Sibabrata Mukhopadhyay ,  Mumu Chakraborty ,  Tulika Mukherjee ,  Arun Bandyopadhyay ,  Dipak Kar ,  Tanima Banerjee ,  Aditya Konar ,  Debaprasad Jana ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Balram Ghosh ,  Mabalirajan Ulaganathan ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Gurdarshan Singh ,  Bholanath Paul ,  Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety

IPC分类号： C07D209/82 ,  C07D209/88 ,  A61K31/403

CPC分类号： C07D209/86 ,  A61K31/404

摘要： The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthma and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients.Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below: wherein R1=H or OCH3; R2═CH3 or CHO; R3═H or OCH3; R4═H or OCH3 Herbal route for the isolation of compound of general formula 1 from the bark of plant Murraya Koenigii and chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.

摘要翻译： 本发明涉及一种治疗支气管哮喘和慢性阻塞性肺疾病（COPD）的方法，其包括向患有哮喘和COPD的患者施用有效剂量的咔唑衍生物或其盐，任选地与药学上可接受的赋形剂。 用作磷酸二酯酶-4（PDE-4）酶抑制剂的通式1化合物的结构式，用于治疗哮喘和哮喘相关疾病的信号分子抑制剂如下：其中R1 = H或OCH3; R2 = CH3或CHO; R3 = H或OCH3; R4 = H或OCH3用于从植物Murraya Koenigii的树皮中分离通式1的化合物的草药路线以及用于从碱性化合物如香草醛制备这些化合物的化学途径也被报道。

公开(公告)号：US20120283263A1

公开(公告)日：2012-11-08

申请号：US13321445

申请日：2010-12-31

申请人： Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

发明人： Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

IPC分类号： A61K31/53 ,  A61P11/06 ,  C12Q1/18 ,  C07D403/14

CPC分类号： C07D403/14 ,  A61K31/53 ,  C07D251/50 ,  C07D251/52

摘要： A novel heterocyclic compound belonging to ‘triazine-aryl-bis-indoles’, useful for the treatment of asthma. The pathway by which this compound inhibits asthma is also demonstrated. The present invention also provides a process for the preparation of above compounds and their derivatives are presented.

摘要翻译： 属于三嗪 - 芳基 - 双 - 吲哚的新型杂环化合物，可用于治疗哮喘。 还证明了该化合物抑制哮喘的途径。 本发明还提供了制备上述化合物的方法及其衍生物。

公开(公告)号：US09085559B2

公开(公告)日：2015-07-21

申请号：US13321445

申请日：2010-12-31

申请人： Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

发明人： Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety ,  Arun Bandyopadhyay ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Balaram Ghosh ,  Mabalirajan Ulaganathan ,  Sakshi Balwani ,  Bholanath Paul ,  Ashok Kumar Saxena

IPC分类号： C07D403/14 ,  C07D251/50 ,  C07D251/52 ,  A61K31/53 ,  A61P11/06

CPC分类号： C07D403/14 ,  A61K31/53 ,  C07D251/50 ,  C07D251/52

摘要： A novel heterocyclic compound belonging to ‘triazine-aryl-bis-indoles’, useful for the treatment of asthma. The pathway by which this compound inhibits asthma is also demonstrated. The present invention also provides a process for the preparation of above compounds and their derivatives are presented.

摘要翻译： 属于“三嗪 - 芳基 - 双 - 吲哚”的新型杂环化合物，可用于治疗哮喘。 还证明了该化合物抑制哮喘的途径。 本发明还提供了制备上述化合物的方法及其衍生物。

公开(公告)号：US20140135393A1

公开(公告)日：2014-05-15

申请号：US14110869

申请日：2012-04-11

申请人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Pal ,  Nahid Ali ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Chowdhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Prayot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

发明人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Pal ,  Nahid Ali ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Chowdhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Prayot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

IPC分类号： C07C39/19 ,  C07C251/40 ,  C07D317/50 ,  C07C255/36 ,  C07C69/732 ,  C07C69/017 ,  C07C251/66

CPC分类号： C07C39/19 ,  A61K31/05 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

摘要翻译： 本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。 本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。 本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。 通式1的化合物可用于减少血管周围和支气管炎。

公开(公告)号：US09302967B2

公开(公告)日：2016-04-05

申请号：US14110869

申请日：2012-04-11

申请人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Choudhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Pradyot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

发明人： Santu Bandyopadhyay ,  Balaram Ghosh ,  Parasuraman Jaisankar ,  Bikas Chandra Pal ,  Siddhartha Roy ,  Bholanath Paul ,  Arjun Ram ,  Ulaganathan Mabalirajan ,  Nahid Ali ,  Arun Bandopadhyay ,  Aditya Konar ,  Jayashree Bagchi Chakraborty ,  Indrani Choudhury Mukherjee ,  Jaydeep Chaudhuri ,  Sanjit Kumar Mahato ,  Anirban Manna ,  Roma Sinha ,  Pradyot Bhattacharya ,  Jayaraman Vinayagam ,  Deba Prasad Jana ,  Sushovan Chowdhury

IPC分类号： A61K31/14 ,  A61K31/05 ,  C07C39/19 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

CPC分类号： C07C39/19 ,  A61K31/05 ,  A61K31/15 ,  A61K31/215 ,  A61K31/277 ,  A61K31/36 ,  C07C69/017 ,  C07C69/732 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07D317/50

摘要： The present invention relates to compounds of general formula 1 for the treatment of bronchial asthma by inhibition of IL-4 or IL-5 pathway inhibition. The present invention also relates to the use of compound of general formula 1 for the treatment of bronchial by inhibition of IL-4 or IL-5 pathway. The present invention also relates to the method of treating asthma by inhibition of IL-4 or IL-5 pathway by administration of compound or said composition through oral, intranasal, route or by inhalation to a mammal in need thereof. Compound of general formula 1 may be used for reducing perivascular and peribronchial inflammation.

摘要翻译： 本发明涉及通过抑制IL-4或IL-5途径抑制来治疗支气管哮喘的通式1的化合物。 本发明还涉及通式1化合物通过抑制IL-4或IL-5途径治疗支气管的用途。 本发明还涉及通过口服，鼻内，途径或通过吸入需要的哺乳动物施用化合物或所述组合物来抑制IL-4或IL-5途径来治疗哮喘的方法。 通式1的化合物可用于减少血管周围和支气管炎。

公开(公告)号：US09408888B2

公开(公告)日：2016-08-09

申请号：US13980701

申请日：2012-01-30

申请人： Amlanjyoti Dhar ,  Shampa Mallick ,  Israr Ahmed ,  Aditya Konar ,  Santu Bandyopadhyay ,  Siddhartha Roy

发明人： Amlanjyoti Dhar ,  Shampa Mallick ,  Israr Ahmed ,  Aditya Konar ,  Santu Bandyopadhyay ,  Siddhartha Roy

IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K9/00 ,  C07K14/47 ,  A61K45/06 ,  C07K14/00

CPC分类号： A61K38/16 ,  A61K9/0019 ,  A61K38/10 ,  A61K45/06 ,  C07K14/00 ,  C07K14/47 ,  A61K2300/00

摘要： The present invention describes a novel bivalent helically constrained peptide targeted against S100B that is an effective anti-cancer drug against cancers that over-express S100B. This helix mimetic targeted against S100B induces rapid apoptosis in cancer cells that over-express a calcium binding protein S100B through simultaneous inhibition of key growth pathways including activation of p53.

摘要翻译： 本发明描述了针对S100B的新型二价螺旋约束肽，其是针对过表达S100B的癌症的有效抗癌药物。 靶向S100B的这种螺旋模拟物通过同时抑制关键生长途径（包括p53的激活）诱导过度表达钙结合蛋白S100B的癌细胞中的快速凋亡。

公开(公告)号：US20140155331A1

公开(公告)日：2014-06-05

申请号：US13980701

申请日：2012-01-30

申请人： Amlanjyoti Dhar ,  Shampa Mallick ,  Israr Ahmed ,  Aditya Konar ,  Santu Bandyopadhyay ,  Siddhartha Roy

发明人： Amlanjyoti Dhar ,  Shampa Mallick ,  Israr Ahmed ,  Aditya Konar ,  Santu Bandyopadhyay ,  Siddhartha Roy

IPC分类号： A61K38/16 ,  C07K14/00

CPC分类号： A61K38/16 ,  A61K9/0019 ,  A61K38/10 ,  A61K45/06 ,  C07K14/00 ,  C07K14/47 ,  A61K2300/00

摘要： The present invention describes a novel bivalent helically constrained peptide targeted against S100B that is an effective anti-cancer drug against cancers that over-express S100B. This helix mimetic targeted against S100B induces rapid apoptosis in cancer cells that over-express a calcium binding protein S100B through simultaneous inhibition of key growth pathways including activation of p53.

摘要翻译： 本发明描述了针对S100B的新型二价螺旋约束肽，其是针对过表达S100B的癌症的有效抗癌药物。 靶向S100B的这种螺旋模拟物通过同时抑制关键生长途径（包括p53的激活）诱导过度表达钙结合蛋白S100B的癌细胞中的快速凋亡。

公开(公告)号：US20120190738A1

公开(公告)日：2012-07-26

申请号：US13144263

申请日：2010-01-12

申请人： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

发明人： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

IPC分类号： A61K31/36 ,  A61K31/225 ,  C07C215/54 ,  A61K31/138 ,  C07C255/33 ,  A61P35/02 ,  A61K31/15 ,  C07D317/50 ,  C07C39/10 ,  A61K31/05 ,  A61P35/00 ,  C07C69/353 ,  A61K31/277

CPC分类号： C07D317/06 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07C255/38

摘要： The present invention relates to compounds of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

摘要翻译： 本发明涉及通过抑制PI3-Akt途径或诱导NO而治疗恶性肿瘤的通式I化合物。 本发明还涉及通式I的化合物用于通过抑制PI3-Akt途径和或诱导NO而治疗恶性肿瘤的用途。 本发明还涉及通过向有需要的哺乳动物施用化合物或所述组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。

公开(公告)号：US09290473B2

公开(公告)日：2016-03-22

申请号：US13144263

申请日：2010-01-12

申请人： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

发明人： Santu Bandyopadhyay ,  Bikas Chandra Pal ,  Jaisankar Parasuraman ,  Siddhartha Roy ,  Jayashree Bagchi Chakrabotry ,  Indrani Choudhury Mukherjee ,  Sanjit Kumar Mahato ,  Aditya Konar ,  Srabanti Rakshit ,  Labanya Mandal ,  Dipyaman Ganguly ,  Kausik Paul ,  Anirban Manna ,  Jayaraman Vinayagam ,  Churala Pal

IPC分类号： A61K31/36 ,  C07C215/54 ,  C07C255/33 ,  C07C39/10 ,  C07D317/06 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07C255/38

CPC分类号： C07D317/06 ,  C07C251/40 ,  C07C251/66 ,  C07C255/36 ,  C07C255/38

摘要： The present invention relates to compounds of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula 1 for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.

摘要翻译： 本发明涉及用于通过抑制PI3-Akt途径和或诱导NO来治疗恶性肿瘤的通式1的化合物。 本发明还涉及通式1的化合物用于通过抑制PI3-Akt途径和或诱导NO而治疗恶性肿瘤的用途。 本发明还涉及通过向有需要的哺乳动物施用化合物或所述组合物来抑制PI3-Akt通路和/或诱导NO治疗恶性肿瘤的方法。

公开(公告)号：US08843394B2

公开(公告)日：2014-09-23

申请号：US12818349

申请日：2010-06-18

申请人： Fei Cao ,  Shaoyu Zhou ,  Siddhartha Roy ,  Michael Elizarov ,  Zhuoqing Wu ,  James Zhang

发明人： Fei Cao ,  Shaoyu Zhou ,  Siddhartha Roy ,  Michael Elizarov ,  Zhuoqing Wu ,  James Zhang

IPC分类号： G06Q30/00 ,  G06Q30/02

CPC分类号： G06Q30/02 ,  G06Q30/0241 ,  G06Q30/0244 ,  G06Q30/0255

摘要： Systems and methods for mapping identifiers are provided. Activity logs illustrate activities and/or events associated with a plurality of identifiers. The identifiers may be registered identifiers, unregistered identifiers, or a combination thereof. When at least two identifiers share a linking attribute, the at least two identifiers may be mapped to one another, along with information associated therewith (if any) such as a user profile. Each subsequent line of an activity line may also be mapped to the identifiers of the initial single line when a linking attribute or an overlapping identifier is present. A number of identifiers associated with each other may be increased by mapping identifiers and, thus, a targeted audience for a customized advertisement may, in turn, be increased.

摘要翻译： 提供了映射标识符的系统和方法。 活动日志示出与多个标识符相关联的活动和/或事件。 标识符可以是注册标识符，未注册标识符或其组合。 当至少两个标识符共享链接属性时，可以将至少两个标识符与其相关联的信息（如果有的话）诸如用户简档映射到彼此。 当存在链接属性或重叠标识符时，活动行的每个后续行也可以映射到初始单行的标识符。 可以通过映射标识符来增加彼此关联的多个标识符，从而可以增加定制广告的目标受众。