公开(公告)号：US08519154B2

公开(公告)日：2013-08-27

申请号：US13365979

申请日：2012-02-03

申请人： Sibabrata Mukhopadhyay ,  Mumu Chakraborty ,  Tulika Mukherjee ,  Arun Bandyopadhyay ,  Dipak Kar ,  Tanima Banerjee ,  Aditya Konar ,  Debaprasad Jana ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Balram Ghosh ,  Mabalirajan Ulaganathan ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Gurdarshan Singh ,  Bholanath Paul ,  Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety

发明人： Sibabrata Mukhopadhyay ,  Mumu Chakraborty ,  Tulika Mukherjee ,  Arun Bandyopadhyay ,  Dipak Kar ,  Tanima Banerjee ,  Aditya Konar ,  Debaprasad Jana ,  Siddhartha Roy ,  Santu Bandyopadhyay ,  Balram Ghosh ,  Mabalirajan Ulaganathan ,  Rakesh Kamal Johri ,  Subhash Chander Sharma ,  Gurdarshan Singh ,  Bholanath Paul ,  Vasanta Madhava Sharma Gangavaram ,  Jhillu Singh Yadav ,  Radha Krishna Palakodety

IPC分类号： C07D209/82 ,  C07D209/88 ,  A61K31/403

CPC分类号： C07D209/86 ,  A61K31/404

摘要： The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthma and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients.Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below: wherein R1=H or OCH3; R2═CH3 or CHO; R3═H or OCH3; R4═H or OCH3 Herbal route for the isolation of compound of general formula 1 from the bark of plant Murraya Koenigii and chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.

摘要翻译： 本发明涉及一种治疗支气管哮喘和慢性阻塞性肺疾病（COPD）的方法，其包括向患有哮喘和COPD的患者施用有效剂量的咔唑衍生物或其盐，任选地与药学上可接受的赋形剂。 用作磷酸二酯酶-4（PDE-4）酶抑制剂的通式1化合物的结构式，用于治疗哮喘和哮喘相关疾病的信号分子抑制剂如下：其中R1 = H或OCH3; R2 = CH3或CHO; R3 = H或OCH3; R4 = H或OCH3用于从植物Murraya Koenigii的树皮中分离通式1的化合物的草药路线以及用于从碱性化合物如香草醛制备这些化合物的化学途径也被报道。

公开(公告)号：US20120202868A1

公开(公告)日：2012-08-09

申请号：US13365979

申请日：2012-02-03

申请人： Sibabrata MUKHOPADHYAY ,  Mumu CHAKRABORTY ,  Tulika MUKHERJEE ,  Arun BANDYOPADHYAY ,  Dipak KAR ,  Tanima BANERJEE ,  Aditya KONAR ,  Debaprasad JANA ,  Siddhartha ROY ,  Santu BANDYOPADHYAY ,  Balram GHOSH ,  Mabalirajan ULAGANATHAN ,  Rakesh Kamal JOHRI ,  Subhash Chander SHARMA ,  Gurdarshan SINGH ,  Bholanath PAUL ,  Vasanta Madhava Sharma GANGAVARAM ,  Jhillu Singh YADAV ,  Radha Krishna PALAKODETY

发明人： Sibabrata MUKHOPADHYAY ,  Mumu CHAKRABORTY ,  Tulika MUKHERJEE ,  Arun BANDYOPADHYAY ,  Dipak KAR ,  Tanima BANERJEE ,  Aditya KONAR ,  Debaprasad JANA ,  Siddhartha ROY ,  Santu BANDYOPADHYAY ,  Balram GHOSH ,  Mabalirajan ULAGANATHAN ,  Rakesh Kamal JOHRI ,  Subhash Chander SHARMA ,  Gurdarshan SINGH ,  Bholanath PAUL ,  Vasanta Madhava Sharma GANGAVARAM ,  Jhillu Singh YADAV ,  Radha Krishna PALAKODETY

IPC分类号： A61K31/403 ,  A61P11/06 ,  C07D209/86

CPC分类号： C07D209/86 ,  A61K31/404

摘要： The present invention relates to a method for the treatment of bronchial asthma and chronic obstructive pulmonary disease (COPD) comprising administering to the patient suffering from asthama and COPD an effective dose of carbazole derivatives or salt thereof, optionally along with pharmaceutically acceptable excipients. Structural formula of the compounds of general formula 1 useful as phosphodiesterase-4 (PDE-4) enzyme inhibitors, inhibitor for signalling molecule for the treatment of asthma and asthma related diseases is given below: wherein R1=H or OCH3; R2═CH3 or CHO; R3═H or OCH3; R4═H or OCH3 Herbal route for the isolation of compound of general formula 1 from the bark of plant Murraya Koenigii and chemical route for the preparation of such compounds from basic compounds such as vanillin is also reported.

摘要翻译： 本发明涉及一种治疗支气管哮喘和慢性阻塞性肺疾病（COPD）的方法，其包括向患有哮喘和COPD的患者施用有效剂量的咔唑衍生物或其盐，任选地与药学上可接受的赋形剂。 用作磷酸二酯酶-4（PDE-4）酶抑制剂的通式1化合物的结构式，用于治疗哮喘和哮喘相关疾病的信号分子抑制剂如下：其中R1 = H或OCH3; R2 = CH3或CHO; R3 = H或OCH3; R4 = H或OCH3用于从植物Murraya Koenigii的树皮中分离通式1的化合物的草药途径以及用于从碱性化合物如香草醛制备这些化合物的化学途径也被报道。