Invention Grant
US08575123B2 Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
有权
通过将靶向配体与内体分解组分结合来进行核酸的位点特异性递送
- Patent Title: Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
- Patent Title (中): 通过将靶向配体与内体分解组分结合来进行核酸的位点特异性递送
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Application No.: US12936961Application Date: 2009-04-10
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Publication No.: US08575123B2Publication Date: 2013-11-05
- Inventor: Muthiah Manoharan , Kallanthottathil G. Rajeev , David Butler , Muthusamy Jayaraman
- Applicant: Muthiah Manoharan , Kallanthottathil G. Rajeev , David Butler , Muthusamy Jayaraman
- Applicant Address: CA Burnaby, BC
- Assignee: Tekmira Pharmaceuticals Corporation
- Current Assignee: Tekmira Pharmaceuticals Corporation
- Current Assignee Address: CA Burnaby, BC
- Agency: Viksnins Harris & Padys PLLP
- International Application: PCT/US2009/040274 WO 20090410
- International Announcement: WO2009/126933 WO 20091015
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/11 ; C12N15/00 ; A01N63/00 ; A01N65/00
Abstract:
The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.
Public/Granted literature
- US20110123520A1 SITE-SPECIFIC DELIVERY OF NUCLEIC ACIDS BY COMBINING TARGETING LIGANDS WITH ENDOSOMOLYTIC COMPONENTS Public/Granted day:2011-05-26
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