- 专利标题： Ketoreductase polypeptides for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate
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申请号： US13329986申请日： 2011-12-19
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公开(公告)号： US08617853B2公开(公告)日： 2013-12-31
- 发明人: Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James Lalonde , Gjalt Huisman
- 申请人： Jack Liang , Birthe Borup , Vesna Mitchell , Emily Mundorff , James Lalonde , Gjalt Huisman
- 申请人地址： US CA Redwood City
- 专利权人： Codexis, Inc.
- 当前专利权人： Codexis, Inc.
- 当前专利权人地址： US CA Redwood City
- 代理机构： Codexis, Inc.
- 主分类号： C12P17/12
- IPC分类号： C12P17/12 ; C12N9/00 ; C12N9/04 ; C12N1/20 ; C12N15/00 ; C07H21/04
摘要：
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.