A method for applying and maintaining optimal tissue compression with a staple includes piercing tissue with deformable distal ends of staple legs, each distal end defining a stapling point shaped to pierce material, the two staple legs coupled to each other at base ends thereof by a bridge and together forming a substantially U-shaped staple body. The two staple legs enter the tissue until the tissue applies a compressive force to a compression device disposed at least partly between the two staple legs. The compression device has a compression surface movably disposed between the two staple legs and a compression resistor that is connected to the bridge and to the compression surface and operable to resist movement of the compression surface towards the bridge with a force. The two staple legs are deformed to maintain the compressive force between the tissue and the compression device.