发明授权
US08685729B2 Heterologous expression of extremophile heat shock proteins and chaperones in microorganisms to increase tolerance to toxic compounds
有权
极微热热休克蛋白和分子伴侣在微生物中的异源表达，以增加对有毒化合物的耐受性
- 专利标题： Heterologous expression of extremophile heat shock proteins and chaperones in microorganisms to increase tolerance to toxic compounds
- 专利标题（中）： 极微热热休克蛋白和分子伴侣在微生物中的异源表达，以增加对有毒化合物的耐受性
-
申请号： US12528620申请日： 2008-02-26
-
公开(公告)号： US08685729B2公开(公告)日： 2014-04-01
- 发明人: Douglas S. Clark , Timothy Whitehead , Frank T. Robb , Pongpan Laksanalamai , Anchalee Jiemjit
- 申请人： Douglas S. Clark , Timothy Whitehead , Frank T. Robb , Pongpan Laksanalamai , Anchalee Jiemjit
- 申请人地址： US CA Oakland US MD Baltimore
- 专利权人： The Regents of the University of California,University of Maryland, Baltimore
- 当前专利权人： The Regents of the University of California,University of Maryland, Baltimore
- 当前专利权人地址： US CA Oakland US MD Baltimore
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 国际申请： PCT/US2008/054978 WO 20080226
- 国际公布： WO2008/106430 WO 20080904
- 主分类号： C12N5/00
- IPC分类号： C12N5/00 ; C12N1/00 ; C12N1/20 ; C12N15/74 ; C12Q1/02 ; C12P21/06 ; C12P7/06 ; C12P7/16 ; C07K1/00 ; C07H21/04
摘要：
The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating microorganisms. The methods comprise engineering a microorganism of interest to express a heterologous heat-shock protein/chaperone, e.g., Group II chaperonin or a prefoldin such as γ-prefoldin, where the heterologous protein is from an extremophile, such as an archaean.