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1.发明授权Heterologous expression of extremophile heat shock proteins and chaperones in microorganisms to increase tolerance to toxic compounds 有权极微热热休克蛋白和分子伴侣在微生物中的异源表达，以增加对有毒化合物的耐受性公开(公告)号：US08685729B2
公开(公告)日：2014-04-01
申请号：US12528620
申请日：2008-02-26
IPC分类号： C12N5/00 , C12N1/00 , C12N1/20 , C12N15/74 , C12Q1/02 , C12P21/06 , C12P7/06 , C12P7/16 , C07K1/00 , C07H21/04
CPC分类号： C07K14/195 , Y02E50/17
摘要： The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating microorganisms. The methods comprise engineering a microorganism of interest to express a heterologous heat-shock protein/chaperone, e.g., Group II chaperonin or a prefoldin such as γ-prefoldin, where the heterologous protein is from an extremophile, such as an archaean.
摘要翻译： 本发明提供了增加微生物对毒性剂如溶剂的耐受性的方法和组合物; 并用于增加溶剂产生微生物的溶剂生产。 所述方法包括将感兴趣的微生物工程化以表达异源热休克蛋白/伴侣，例如II型伴侣蛋白或诸如γ-预折蛋白之类的预折合蛋白，其中异源蛋白质来自极端亲本，例如古细菌。
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2.发明申请HETEROLOGOUS EXPRESSION OF EXTREMOPHILE HEAT SHOCK PROTEINS AND CHAPERONES IN MICROORGANISMS TO INCREASE TOLERANCE TO TOXIC COMPOUNDS 有权微生物中超临界热休克蛋白和葛根酮的异位表达增加对毒性化合物的耐受性公开(公告)号：US20110045554A1
公开(公告)日：2011-02-24
申请号：US12528620
申请日：2008-02-26
IPC分类号： C12P7/64 , C12P1/00 , C12P7/26 , C12P7/16 , C12P7/06 , C12P5/00 , C12P1/04 , C12P1/02 , C12N15/63 , C12N1/00 , C12N1/21 , C12N1/15 , C12N1/19 , C12N1/13 , C12N15/81 , C12N15/74 , C12N15/80 , C12N15/70
CPC分类号： C07K14/195 , Y02E50/17
摘要： The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating microorganisms. The methods comprise engineering a microorganism of interest to express a heterologous heat-shock protein/chaperone, e.g., Group II chaperonin or a prefoldin such as γ-prefoldin, where the heterologous protein is from an extremophile, such as an archaean.
摘要翻译： 本发明提供了增加微生物对毒性剂如溶剂的耐受性的方法和组合物; 并用于增加溶剂产生微生物的溶剂生产。 所述方法包括将感兴趣的微生物工程化以表达异源热休克蛋白/伴侣，例如II型伴侣蛋白或诸如γ-预折蛋白之类的预折合蛋白，其中异源蛋白质来自极端亲本，例如古细菌。
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