发明授权
- 专利标题: Peptide linkers for effective multivalent peptide binding
- 专利标题(中): 用于有效多价肽结合的肽接头
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申请号: US12632831申请日: 2009-12-08
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公开(公告)号: US08697654B2公开(公告)日: 2014-04-15
- 发明人: Qiong Cheng , Stephen R. Fahnestock , Hongxian He , Kristy N. Kostichka , Hong Wang
- 申请人: Qiong Cheng , Stephen R. Fahnestock , Hongxian He , Kristy N. Kostichka , Hong Wang
- 申请人地址: US DE Wilmington
- 专利权人: E I du Pont de Nemours and Company
- 当前专利权人: E I du Pont de Nemours and Company
- 当前专利权人地址: US DE Wilmington
- 主分类号: A61K38/16
- IPC分类号: A61K38/16 ; A61K8/00 ; A61Q5/00 ; A61C9/00 ; A61P17/00
摘要:
Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
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