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公开(公告)号：US08697654B2
公开(公告)日：2014-04-15
申请号：US12632831
申请日：2009-12-08
CPC分类号： A61K47/48338 , A61K8/19 , A61K8/64 , A61K2800/94 , A61Q5/00 , A61Q5/065 , C07K14/001 , C07K2319/70 , G01N33/6803 , G06F19/16
摘要： Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
摘要翻译： 对目标表面具有亲和性的短单链肽通常缺乏某些商业应用所需的结合耐久性。 提高耐久性的一种方法是通过使用肽接头连接在一起的结合序列来促进多价结合。 然而，所得到的单链结合肽通常具有接头熵。 已经发现，当将多个结合序列连接在一起时，使用刚性肽接头增强所得单链肽的结合亲和力。
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公开(公告)号：US07105296B2
公开(公告)日：2006-09-12
申请号：US10230026
申请日：2002-08-28
申请人： Michael G. Bramucci , Patricia C. Brzostowicz , Kristy N Kostichka , Vasantha Nagarajan , Pierre E. Rouviere , Stuart M. Thomas
发明人： Michael G. Bramucci , Patricia C. Brzostowicz , Kristy N Kostichka , Vasantha Nagarajan , Pierre E. Rouviere , Stuart M. Thomas
CPC分类号： C12N9/0073 , C12P17/08
摘要： Genes have been isolated from a variety of bacteria encoding Baeyer-Villiger monooxygenase activity. The genes and their products are useful for the conversion of ketones to the corresponding esters. A series of motifs, common to all genes, has been identified as diagnostic for genes encoding proteins of this activity.
摘要翻译： 已经从编码Baeyer-Villiger单加氧酶活性的各种细菌中分离出基因。 基因及其产物可用于将酮转化为相应的酯。 已经鉴定了所有基因共有的一系列基序作为编码该活性蛋白质的基因的诊断。
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公开(公告)号：US20100158837A1
公开(公告)日：2010-06-24
申请号：US12632827
申请日：2009-12-08
CPC分类号： A61K8/19 , A61K8/64 , A61K2800/43 , A61K2800/884 , A61Q1/00 , A61Q5/065 , A61Q5/12 , A61Q11/00 , A61Q19/00
摘要： Peptides having strong affinity for iron oxide pigment particles have been identified. Peptide-based reagents comprising at least one of the present iron oxide-based pigment-binding peptides and at least one body surface-binding peptide are described. The peptide-based reagents may be used in conjunction with at least one iron oxide-based pigment to color body surfaces.
摘要翻译： 已经鉴定出对氧化铁颜料颗粒具有强亲合力的肽。 描述了包含至少一种本发明的氧化铁基颜料结合肽和至少一种身体表面结合肽的基于肽的试剂。 基于肽的试剂可以与至少一种氧化铁基颜料结合使用以使身体表面着色。
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公开(公告)号：US20100158823A1
公开(公告)日：2010-06-24
申请号：US12632831
申请日：2009-12-08
CPC分类号： A61K47/48338 , A61K8/19 , A61K8/64 , A61K2800/94 , A61Q5/00 , A61Q5/065 , C07K14/001 , C07K2319/70 , G01N33/6803 , G06F19/16
摘要： Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
摘要翻译： 对目标表面具有亲和性的短单链肽通常缺乏某些商业应用所需的结合耐久性。 提高耐久性的一种方法是通过使用肽接头连接在一起的结合序列来促进多价结合。 然而，所得到的单链结合肽通常具有接头熵。 已经发现，当将多个结合序列连接在一起时，使用刚性肽接头增强所得单链肽的结合亲和力。
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公开(公告)号：US07416859B2
公开(公告)日：2008-08-26
申请号：US11069691
申请日：2005-03-01
CPC分类号： C12N15/74
摘要： A plasmid has been isolated from Rhodococcus erythropolis strain AN12 comprising a unique replication protein. The replication protein may be used in a variety of cloning and expression vectors and particularly in shuttle vectors for the expression of heterologous genes in Rhodococcus sp.
摘要翻译： 已经从包含独特复制蛋白的红球菌菌株AN12分离出质粒。 复制蛋白可用于多种克隆和表达载体，特别是用于在红球菌属中表达异源基因的穿梭载体中。
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公开(公告)号：US07034140B2
公开(公告)日：2006-04-25
申请号：US10128713
申请日：2002-04-22
申请人： Michael G. Bramucci , Patricia C. Brzostowicz , Qiong Cheng , Kristy N Kostichka , Pierre E. Rouviere , Vasantha Nagarajan , Luan Tao , Stuart M. Thomas
发明人： Michael G. Bramucci , Patricia C. Brzostowicz , Qiong Cheng , Kristy N Kostichka , Pierre E. Rouviere , Vasantha Nagarajan , Luan Tao , Stuart M. Thomas
CPC分类号： C12N15/52
摘要： Genes have been isolated from Rhodococcus erythropolis AN12 strain encoding the isoprenoid biosynthetic pathway. The genes and gene products are the first isolated from a Rhodococcus strain. The genes and gene products of the present invention may be used in a variety of ways for the production of isoprenoid compounds in a variety of organisms.
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公开(公告)号：US06949362B2
公开(公告)日：2005-09-27
申请号：US10007527
申请日：2001-12-05
IPC分类号： C12N15/09 , C07K14/195 , C12N1/21 , C12N15/31 , C12N15/74 , C12P21/06 , C07H21/02 , C12N1/20 , C12N15/00
CPC分类号： C12N15/74
摘要： A plasmid has been isolated from Rhodococcus erythropolis strain AN12 comprising a unique replication protein. The replication protein may be used in a variety of cloning and expression vectors and particularly in shuttle vectors for the expression of heterologous genes in Rhodococcus sp.
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