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公开(公告)号：US08697654B2
公开(公告)日：2014-04-15
申请号：US12632831
申请日：2009-12-08
CPC分类号： A61K47/48338 , A61K8/19 , A61K8/64 , A61K2800/94 , A61Q5/00 , A61Q5/065 , C07K14/001 , C07K2319/70 , G01N33/6803 , G06F19/16
摘要： Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
摘要翻译： 对目标表面具有亲和性的短单链肽通常缺乏某些商业应用所需的结合耐久性。 提高耐久性的一种方法是通过使用肽接头连接在一起的结合序列来促进多价结合。 然而，所得到的单链结合肽通常具有接头熵。 已经发现，当将多个结合序列连接在一起时，使用刚性肽接头增强所得单链肽的结合亲和力。
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公开(公告)号：US20100158837A1
公开(公告)日：2010-06-24
申请号：US12632827
申请日：2009-12-08
CPC分类号： A61K8/19 , A61K8/64 , A61K2800/43 , A61K2800/884 , A61Q1/00 , A61Q5/065 , A61Q5/12 , A61Q11/00 , A61Q19/00
摘要： Peptides having strong affinity for iron oxide pigment particles have been identified. Peptide-based reagents comprising at least one of the present iron oxide-based pigment-binding peptides and at least one body surface-binding peptide are described. The peptide-based reagents may be used in conjunction with at least one iron oxide-based pigment to color body surfaces.
摘要翻译： 已经鉴定出对氧化铁颜料颗粒具有强亲合力的肽。 描述了包含至少一种本发明的氧化铁基颜料结合肽和至少一种身体表面结合肽的基于肽的试剂。 基于肽的试剂可以与至少一种氧化铁基颜料结合使用以使身体表面着色。
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3.发明授权公开(公告)号：US08273337B2
公开(公告)日：2012-09-25
申请号：US12198358
申请日：2008-08-26
IPC分类号： A61K8/64
CPC分类号： C07K14/001 , A61K8/64 , A61K2800/57 , A61Q5/065 , A61Q5/10 , A61Q5/12
摘要： Peptides have been identified that bind with high affinity to hair. Peptide-based hair reagents formed by coupling a hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of at least one hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively.
摘要翻译： 已经鉴定出以高亲和力结合头发的肽。 描述了通过将毛发结合肽偶联到有益剂形成的基于肽的毛发试剂。 基于肽的毛发试剂包括基于肽的护发素和头发着色剂。 基于肽的护发素和毛发着色剂分别由至少一种与头发调理剂或着色剂偶联的毛发结合肽组成。
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公开(公告)号：US20100247457A1
公开(公告)日：2010-09-30
申请号：US12698172
申请日：2010-02-02
申请人： DOUGLAS ROBERT ANTON , Scott D. Cunningham , Stephen R. Fahnestock , Kari A. Fosser , Hong Wang
发明人： DOUGLAS ROBERT ANTON , Scott D. Cunningham , Stephen R. Fahnestock , Kari A. Fosser , Hong Wang
CPC分类号： A61K8/25 , A61K8/0241 , A61K8/29 , A61K8/64 , A61K8/731 , A61K2800/412 , A61K2800/43 , A61K2800/614 , A61Q11/00 , C07K7/08 , C07K14/001
摘要： Peptide-based reagents comprising at least one tooth surface-binding peptide for delivery of at least one polymer-coated white colorant to the surface of teeth are provided. The peptide-based reagent may comprise at least one tooth-binding peptide coupled to, either directly or through one or more spacers, a polymer-binding peptide capable of binding to the polymeric coating on a polymer-coated white colorant. Methods of delivering a polymer-coated white colorant to a tooth surface are also provided as well as oral care compositions comprising the present peptide-based reagents. The peptide-based reagents may be used in conjunction with at least one polymer-coated white colorant to improve the cosmetic appearance of teeth.
摘要翻译： 提供了包含用于将至少一种聚合物涂覆的白色着色剂递送到牙齿表面的至少一个牙齿表面结合肽的基于肽的试剂。 基于肽的试剂可以包含至少一种与粘合到聚合物涂覆的白色着色剂上的与聚合物涂层结合的聚合物结合肽直接或通过一个或多个间隔物偶联的牙结合肽。 还提供将聚合物涂覆的白色着色剂递送到牙齿表面的方法以及包含本发明的基于肽的试剂的口腔护理组合物。 基于肽的试剂可以与至少一种聚合物涂覆的白色着色剂结合使用以改善牙齿的美容外观。
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5.发明授权Zein-based peptide tags for the expression and purification of bioactive peptides 失效用于表达和纯化生物活性肽的基于Zein的肽标签公开(公告)号：US07732569B2
公开(公告)日：2010-06-08
申请号：US11641936
申请日：2006-12-19
IPC分类号： C07K1/00
CPC分类号： C07K14/425 , C07K2319/00
摘要： Zein-based peptide tags, referred to here as inclusion body tags (IBTs), are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that is insoluble and contained within inclusion bodies in the cell and/or cell lysate. The inclusion bodies may then be purified and the protein of interest may be isolated after cleavage from the inclusion body tag.
摘要翻译： 公开了用于产生不溶性融合肽的基于Zein的肽标签，这里称为包涵体标签（IBT）。 融合肽包含可操作地连接到目的肽的至少一种包涵体标签。 融合肽在宿主细胞中的表达产生不溶性并且包含在细胞和/或细胞裂解物中的包涵体内的产物。 然后可以纯化包涵体，并且在从包涵体标签切割后可以分离感兴趣的蛋白质。
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公开(公告)号：US20080206809A1
公开(公告)日：2008-08-28
申请号：US11516362
申请日：2006-09-05
IPC分类号： C12P21/06 , C07K14/195 , C12N1/21 , C07H21/04
CPC分类号： A61K8/64 , A61K2800/94 , A61Q3/00 , A61Q5/10 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61Q19/04 , C07K2319/00
摘要： Peptide tags, referred to here as inclusion body tags, are disclosed and are useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that is insoluble and contained within inclusion bodies in the cell and/or cell lysate. The inclusion bodies may then be purified and the protein of interest may be isolated after cleavage from the inclusion body tag.
摘要翻译： 肽标签，这里称为包涵体标签，并且可用于产生不溶性融合肽。 融合肽包含可操作地连接到目的肽的至少一种包涵体标签。 融合肽在宿主细胞中的表达产生不溶性并且包含在细胞和/或细胞裂解物中的包涵体内的产物。 然后可以纯化包涵体，并且在从包涵体标签中切割后可以分离感兴趣的蛋白质。
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公开(公告)号：US20120321581A1
公开(公告)日：2012-12-20
申请号：US13330171
申请日：2011-12-19
申请人： Robert DiCosimo , Scott D. Cunningham , Stephen R. Fahnestock , Tanja Maria Gruber , Mark S. Payne , Pierre E. Rouviere , Linda Jane Solomon , Hong Wang
发明人： Robert DiCosimo , Scott D. Cunningham , Stephen R. Fahnestock , Tanja Maria Gruber , Mark S. Payne , Pierre E. Rouviere , Linda Jane Solomon , Hong Wang
CPC分类号： C12N9/18 , C07K16/16 , C07K19/00 , C07K2319/01 , C11D3/38636 , C11D3/38681 , C12N9/14 , C12N9/2437 , C12P7/40 , C12P7/54
摘要： Disclosed herein are compositions and methods to target enzymatic peracid production to a target surface. The peracid benefit agent produced by the targeted perhydrolytic enzyme can be use for a variety of applications such as bleaching, whitening, disinfecting, destaining, deodorizing, and combinations thereof. Specifically, a fusion protein comprising a perhydrolytic enzyme and at least one peptidic component having affinity for a target surface (excluding body surfaces and oral care surfaces) is used in combination with a suitable substrate and a source of peroxygen to enzymatically produce a peracid on or near the surface of the target material. In a preferred aspect, the target surface is a cellulosic material.
摘要翻译： 本文公开了将酶过氧酸生产靶向靶表面的组合物和方法。 由靶向的水解酶产生的过酸有益剂可用于各种应用，例如漂白，增白，消毒，脱色，除臭及其组合。 特别地，包含过水解酶和至少一种对靶表面（不包括身体表面和口腔护理表面）具有亲和性的肽成分的融合蛋白与合适的底物和过氧源组合使用以在其上或 靠近目标材料的表面。 在优选的方面，目标表面是纤维素材料。
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8.发明申请DYED-HAIR-BINDING PEPTIDES AND PEPTIDE-BASED HAIR REAGENTS FOR PERSONAL CARE 失效用于个人护理的染发头发胶原和基于肽的头发试剂公开(公告)号：US20090074694A1
公开(公告)日：2009-03-19
申请号：US12198382
申请日：2008-08-26
CPC分类号： C07K14/001 , A61K8/64 , A61K2800/57 , A61Q5/065 , A61Q5/10 , A61Q5/12
摘要： Peptides have been identified that bind with high affinity to dyed hair. Peptide-based hair reagents formed by coupling a dyed-hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of a dyed-hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively. The peptide-based hair reagents or the dyed-hair-binding peptides may also be used as a protective sealant to improve color retention of dyed hair.
摘要翻译： 已经鉴定出以高亲和力结合染色的头发的肽。 描述了通过将染色结合肽偶联到有益剂形成的基于肽的毛发试剂。 基于肽的毛发试剂包括基于肽的护发素和头发着色剂。 基于肽的护发素和毛发着色剂分别由与头发调理剂或着色剂偶联的染色结合肽组成。 基于肽的毛发试剂或染色结合肽也可以用作保护性密封剂，以改善染色头发的保色性。
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9.发明申请Identification of peptide tags for the production of insoluble peptides by sequence scanning 审中-公开通过序列扫描鉴定用于产生不溶性肽的肽标签公开(公告)号：US20100234568A1
公开(公告)日：2010-09-16
申请号：US11641981
申请日：2006-12-19
CPC分类号： C12N15/1093 , C12N15/1065 , C40B40/08 , C40B50/06
摘要： A method is provided to identify short peptide tags, referred to here as inclusion body tags (IBTs), useful for the generation of insoluble fusion peptides. A library of genetic constructs were prepared encoding fusion peptides comprising an inclusion body tag of 10-50 contiguous amino acids from a full-length insoluble protein operably linked to a peptide of interest. The library was designed to include a sufficient number of overlapping inclusion body tags to ensure that the entire length of the full-length insoluble protein was represented. Host cells transformed and expressing the genetic constructs were evaluated for inclusion body formation.
摘要翻译： 提供了一种用于鉴定可用于产生不溶性融合肽的短肽标签（本文称为包含体标签（IBT））的方法。 制备遗传构建体文库，编码融合肽，其包含可操作地连接到感兴趣肽的全长不溶性蛋白质的10-50个连续氨基酸的包涵体标签。 该文库旨在包括足够数量的重叠包含体标签，以确保全长不溶性蛋白质的全长被表示。 评估转化并表达遗传构建体的宿主细胞的包涵体形成。
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公开(公告)号：US07795382B2
公开(公告)日：2010-09-14
申请号：US12207963
申请日：2008-09-10
CPC分类号： A61K8/64 , A61K2800/94 , A61Q3/00 , A61Q5/10 , A61Q17/005 , A61Q17/04 , A61Q19/00 , A61Q19/04 , C07K2319/00
摘要： Peptide tags, referred to here as inclusion body tags, are disclosed and are useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that is insoluble and contained within inclusion bodies in the cell and/or cell lysate. The inclusion bodies may then be purified and the protein of interest may be isolated after cleavage from the inclusion body tag.
摘要翻译： 肽标签，这里称为包涵体标签，并且可用于产生不溶性融合肽。 融合肽包含可操作地连接到目的肽的至少一种包涵体标签。 融合肽在宿主细胞中的表达产生不溶性并且包含在细胞和/或细胞裂解物中的包涵体内的产物。 然后可以纯化包涵体，并且在从包涵体标签切割后可以分离感兴趣的蛋白质。
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