Invention Grant
US08808685B2 Method of treatment using organotypically cultured skin tissue comprising NIKS cells that express exogenous HIF-1α
有权
使用包含表达外源HIF-1α的NIKS细胞的组织培养的皮肤组织进行治疗的方法
- Patent Title: Method of treatment using organotypically cultured skin tissue comprising NIKS cells that express exogenous HIF-1α
- Patent Title (中): 使用包含表达外源HIF-1α的NIKS细胞的组织培养的皮肤组织进行治疗的方法
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Application No.: US13195614Application Date: 2011-08-01
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Publication No.: US08808685B2Publication Date: 2014-08-19
- Inventor: Allen R. Comer , B. Lynn Allen-Hoffmann
- Applicant: Allen R. Comer , B. Lynn Allen-Hoffmann
- Applicant Address: US WI Madison
- Assignee: Stratatech Corporation
- Current Assignee: Stratatech Corporation
- Current Assignee Address: US WI Madison
- Agency: Casimir Jones SC
- Main IPC: A01N63/00
- IPC: A01N63/00 ; C12N5/071
Abstract:
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
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