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公开(公告)号：US08580314B2
公开(公告)日：2013-11-12
申请号：US12612284
申请日：2009-11-04
Applicant: Allen R. Comer , B. Lynn Allen-Hoffmann , Barry Steiglitz
Inventor： Allen R. Comer , B. Lynn Allen-Hoffmann , Barry Steiglitz
IPC: A61K35/12
CPC classification number: A61L27/3691 , A61F2/105 , A61L27/3813 , A61L27/54 , A61L27/60 , A61L2430/40
Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
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公开(公告)号：US20100330046A1
公开(公告)日：2010-12-30
申请号：US12784699
申请日：2010-05-21
Applicant: Allen R. Comer , B. Lynn Allen-Hoffmann
Inventor： Allen R. Comer , B. Lynn Allen-Hoffmann
CPC classification number: A61K38/208 , A61K35/12 , A61K48/00 , C07K14/5434 , C12N5/0629 , C12N2501/23 , C12N2510/00
Abstract: The present invention relates generally to compositions for treating patients that have skin cancer or have recently had skin cancers removed. More specifically, the present invention provides human skin substitutes engineered to express exogenous IL-12 and compositions and methods for making human skin substitutes engineered to express exogenous IL-12. In addition, the present invention provides methods for treatment of sites on a patient where skin cancers have been removed with human skin substitutes engineered to express exogenous IL-12.
Abstract translation: 本发明一般涉及用于治疗患有皮肤癌或最近除去皮肤癌的患者的组合物。 更具体地，本发明提供了工程化以表达外源IL-12的人皮肤代用品，以及用于制备人工皮肤代用品以表达外源性IL-12的组合物和方法。 此外，本发明提供了治疗患者皮肤癌已被去除的部位的方法，人类皮肤替代物被工程化以表达外源IL-12。
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3.发明申请METHOD OF TREATMENT USING ORGANOTYPICALLY CULTURED SKIN TISSUE COMPRISING NIKS CELLS THAT EXPRESS EXOGENOUS HIF-1A 有权使用包含表达异源HIF-1A的NIKS细胞的有机培养的皮肤组织进行治疗的方法公开(公告)号：US20110286985A1
公开(公告)日：2011-11-24
申请号：US13195614
申请日：2011-08-01
Applicant: Allen R. Comer , B. Lynn Allen-Hoffmann
Inventor： Allen R. Comer , B. Lynn Allen-Hoffmann
CPC classification number: C07K14/52 , A61K35/12 , C07K14/515 , C12N5/0698 , C12N2501/165 , C12N2501/17 , C12N2502/094 , C12N2502/1323 , C12N2502/99
Abstract: The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
Abstract translation: 本发明涉及体外培养的皮肤组织，特别涉及包含编码血管生成生长因子的外源基因的培养的皮肤组织。 在一些实施方案中，角质形成细胞表达外源血管生成素-1，HIF-1α或VEGF家族的成员，优选VEGF-A。 在特别优选的实施方案中，将角质细胞掺入培养的皮肤组织中。
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4.发明授权Method of treatment using organotypically cultured skin tissue comprising niks cells that express exogenous HIF-1a 有权使用包含表达外源HIF-1a的niks细胞的器官培养的皮肤组织进行治疗的方法公开(公告)号：US07988959B2
公开(公告)日：2011-08-02
申请号：US12886976
申请日：2010-09-21
Applicant: Allen R. Comer , B. Lynn Allen-Hoffmann
Inventor： Allen R. Comer , B. Lynn Allen-Hoffmann
CPC classification number: C07K14/52 , A61K35/12 , C07K14/515 , C12N5/0698 , C12N2501/165 , C12N2501/17 , C12N2502/094 , C12N2502/1323 , C12N2502/99
Abstract: The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
Abstract translation: 本发明涉及体外培养的皮肤组织，特别涉及包含编码血管生成生长因子的外源基因的培养的皮肤组织。 在一些实施方案中，角质形成细胞表达外源血管生成素-1，HIF-1α或VEGF家族的成员，优选VEGF-A。 在特别优选的实施方案中，将角质细胞掺入培养的皮肤组织中。
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Patent Agency Ranking
公开(公告)号：US20110059057A1
公开(公告)日：2011-03-10
申请号：US12886976
申请日：2010-09-21
Applicant: Allen R. Comer , B. Lynn Allen-Hoffmann
Inventor： Allen R. Comer , B. Lynn Allen-Hoffmann
CPC classification number: C07K14/52 , A61K35/12 , C07K14/515 , C12N5/0698 , C12N2501/165 , C12N2501/17 , C12N2502/094 , C12N2502/1323 , C12N2502/99
Abstract: The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
Abstract translation: 本发明涉及体外培养的皮肤组织，特别涉及包含编码血管生成生长因子的外源基因的培养的皮肤组织。 在一些实施方案中，角质形成细胞表达外源血管生成素-1，HIF-1α或VEGF家族的成员，优选VEGF-A。 在特别优选的实施方案中，将角质细胞掺入培养的皮肤组织中。
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6.发明授权公开(公告)号：US06998240B2
公开(公告)日：2006-02-14
申请号：US10166917
申请日：2002-06-11
Applicant: F. Michael Hoffmann , Allen R. Comer
Inventor： F. Michael Hoffmann , Allen R. Comer
CPC classification number: G01N33/6872 , C07K14/4702 , G01N2333/4703
Abstract: A method of screening for selective inhibitors or activators Smad protein function is disclosed. In one embodiment, the invention comprises the steps of (a) obtaining a phosphorylated Smad protein or protein complex, (b) allowing the phosphorylated Smad protein or complex to interact with a target protein or peptide in the presence of a test compound, and (c) analyzing the binding of the phosphorylated Smad complex or protein and the target protein or peptide, wherein a perturbation of binding indicates that the test compound is an inhibitor or activator of Smad-target protein interaction.
Abstract translation: 公开了筛选选择性抑制剂或活化剂Smad蛋白功能的方法。 在一个实施方案中，本发明包括以下步骤：（a）获得磷酸化的Smad蛋白或蛋白质复合物，（b）在受试化合物存在下使磷酸化的Smad蛋白或复合物与靶蛋白或肽相互作用，和 c）分析磷酸化Smad复合物或蛋白质与靶蛋白或肽的结合，其中结合的扰动表明测试化合物是Smad-靶蛋白相互作用的抑制剂或活化剂。
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公开(公告)号：US20100119615A1
公开(公告)日：2010-05-13
申请号：US12612284
申请日：2009-11-04
Applicant: Allen R. Comer , B. Lynn Allen-Hoffmann , Barry Steiglitz
Inventor： Allen R. Comer , B. Lynn Allen-Hoffmann , Barry Steiglitz
CPC classification number: A61L27/3691 , A61F2/105 , A61L27/3813 , A61L27/54 , A61L27/60 , A61L2430/40
Abstract: The present invention relates generally to systems and methods for preparing, storing, shipping and using skin equivalents made by organotypic culture. In particular, the present invention relates to systems and methods for producing, transporting, storing and using skin equivalents produced by organotypic culture at reduced temperatures, preferably from 2-8 degrees Celsius to ambient temperature. The methods include sterile packaging of the grafts so that the sterility and integrity of the package is maintained until the time of use for grafting purposes.
Abstract translation: 本发明一般涉及用于制备，储存，运输和使用由器官培养形成的皮肤等同物的系统和方法。 特别地，本发明涉及用于生产，运输，储存和使用在降低的温度，优选2-8摄氏度至环境温度下由器官培养产生的皮肤当量的系统和方法。 所述方法包括移植物的无菌包装，从而保持包装的无菌性和完整性，直至用于移植目的的使用时间为止。
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8.发明授权Method of treatment using organotypically cultured skin tissue comprising NIKS cells that express exogenous HIF-1α 有权使用包含表达外源HIF-1α的NIKS细胞的组织培养的皮肤组织进行治疗的方法公开(公告)号：US08808685B2
公开(公告)日：2014-08-19
申请号：US13195614
申请日：2011-08-01
Applicant: Allen R. Comer , B. Lynn Allen-Hoffmann
Inventor： Allen R. Comer , B. Lynn Allen-Hoffmann
CPC classification number: C07K14/52 , A61K35/12 , C07K14/515 , C12N5/0698 , C12N2501/165 , C12N2501/17 , C12N2502/094 , C12N2502/1323 , C12N2502/99
Abstract: The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1, HIF-1α, or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
Abstract translation: 本发明涉及体外培养的皮肤组织，特别涉及包含编码血管生成生长因子的外源基因的培养的皮肤组织。 在一些实施方案中，角质形成细胞表达外源血管生成素-1，HIF-1α或VEGF家族的成员，优选VEGF-A。 在特别优选的实施方案中，将角质细胞掺入培养的皮肤组织中。
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公开(公告)号：US07915042B2
公开(公告)日：2011-03-29
申请号：US12392221
申请日：2009-02-25
Applicant: Allen R. Comer , Michael Hoffmann , B. Lynn Allen-Hoffmann
Inventor： Allen R. Comer , Michael Hoffmann , B. Lynn Allen-Hoffmann
CPC classification number: C07K14/52 , A61K35/12 , C07K14/515 , C12N5/0698 , C12N2501/165 , C12N2501/17 , C12N2502/094 , C12N2502/1323 , C12N2502/99
Abstract: The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1 or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.
Abstract translation: 本发明涉及体外培养的皮肤组织，特别涉及包含编码血管生成生长因子的外源基因的培养的皮肤组织。 在一些实施方案中，角质形成细胞表达外源血管生成素-1或VEGF家族的成员，优选VEGF-A。 在特别优选的实施方案中，将角质细胞掺入培养的皮肤组织中。
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