Invention Grant
- Patent Title: Conjugate between a thiophilic solid phase and an oligonucleotide comprising a thiooxonucleotide
- Patent Title (中): 嗜硫菌固相与含有硫代核苷酸的寡核苷酸之间的共轭
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Application No.: US13866412Application Date: 2013-04-19
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Publication No.: US08981070B2Publication Date: 2015-03-17
- Inventor: Simone Budow , Ping Ding , Dieter Heindl , Alfons Nichtl , Frank Seela
- Applicant: Roche Diagnostics Operations, Inc.
- Applicant Address: US IN Indianapolis
- Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee: Roche Diagnostics Operations, Inc.
- Current Assignee Address: US IN Indianapolis
- Agency: Roche Diagnostics Operations, Inc.
- Priority: EP10188515 20101022
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/00 ; C12Q1/68
Abstract:
An oligonucleotide-solid phase conjugate, wherein the solid phase is thiophilic and the oligonucleotide comprises at least one thiooxonucleobase according to Formula I, wherein X is CH or N, R1 is H or NH2, --- indicates a covalent bond, and said oligonucleotide is bound to said solid phase via the sulfur atom of said thiooxonucleotide. Also disclosed are methods for producing such conjugate as well as various uses for such oligonucleotide metal conjugate.
Public/Granted literature
- US20130210009A1 CONJUGATE BETWEEN A THIOPHILIC SOLID PHASE AND AN OLIGONUCLEOTIDE COMPRISING A THIOOXONUCLEOTIDE Public/Granted day:2013-08-15
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