Invention Grant
- Patent Title: Morpholinone compounds as factor IXA inhibitors
- Patent Title (中): 吗啉酮化合物作为因子IXA抑制剂
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Application No.: US12791464Application Date: 2010-06-01
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Publication No.: US08987242B2Publication Date: 2015-03-24
- Inventor: Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Tomokazu Hirabayashi , Santhosh Neelamkavil , Hidemitsu Nishida , Fumihiko Saitoh , Unmesh Shah , Yan Xia
- Applicant: Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Tomokazu Hirabayashi , Santhosh Neelamkavil , Hidemitsu Nishida , Fumihiko Saitoh , Unmesh Shah , Yan Xia
- Applicant Address: US NJ Rahway JP Tokyo
- Assignee: Merck Sharp & Dohme Corp.,Mochida Pharmaceuticals Co., Ltd.
- Current Assignee: Merck Sharp & Dohme Corp.,Mochida Pharmaceuticals Co., Ltd.
- Current Assignee Address: US NJ Rahway JP Tokyo
- Agent Nichole M. Beeler; Catherine D. Fitch
- Main IPC: A61K31/535
- IPC: A61K31/535 ; A01N43/00 ; A61K31/33 ; C07D413/12 ; A61K31/397 ; A61K31/496 ; A61K31/5375 ; A61K31/5377 ; A61K31/54 ; A61K31/7088 ; A61K39/395 ; A61K45/06 ; C07D265/32 ; C07D413/10 ; C07D413/14 ; C07D417/10
Abstract:
The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
Public/Granted literature
- US20110135650A1 MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS Public/Granted day:2011-06-09
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