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公开(公告)号：US08987242B2
公开(公告)日：2015-03-24
申请号：US12791464
申请日：2010-06-01
申请人： Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Tomokazu Hirabayashi , Santhosh Neelamkavil , Hidemitsu Nishida , Fumihiko Saitoh , Unmesh Shah , Yan Xia
发明人： Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Tomokazu Hirabayashi , Santhosh Neelamkavil , Hidemitsu Nishida , Fumihiko Saitoh , Unmesh Shah , Yan Xia
IPC分类号： A61K31/535 , A01N43/00 , A61K31/33 , C07D413/12 , A61K31/397 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/7088 , A61K39/395 , A61K45/06 , C07D265/32 , C07D413/10 , C07D413/14 , C07D417/10
CPC分类号： C07D413/12 , A61K31/397 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/7088 , A61K39/395 , A61K45/06 , C07D265/32 , C07D413/10 , C07D413/14 , C07D417/10 , A61K2300/00
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供本文所述的式（I）化合物或其药学上可接受的盐或溶剂合物。 本发明还提供包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化改变的方法。
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公开(公告)号：US20140057836A1
公开(公告)日：2014-02-27
申请号：US13960343
申请日：2013-08-06
申请人： Thomas BARA , Sathesh Bhat , Dipshika Biswas , Linda Brockunier , Duane Burnette , Samuel Chackalamannil , Mariappan Vasu Cheliah , Austin Chen , Martin Clasby , Vince J. Colandrea , Zhuyan Guo , Yongxin Han , Charles Jayne , Hubert Josien , Karen Marcantonio , Shouwu Miao , Santhosh Neelamkavil , Patrick Pinto , Murali Rajogopalan , Unmesh Shah , Francisco Velazquez , Srikanth Venkatraman , Yan Xia
发明人： Thomas BARA , Sathesh Bhat , Dipshika Biswas , Linda Brockunier , Duane Burnette , Samuel Chackalamannil , Mariappan Vasu Cheliah , Austin Chen , Martin Clasby , Vince J. Colandrea , Zhuyan Guo , Yongxin Han , Charles Jayne , Hubert Josien , Karen Marcantonio , Shouwu Miao , Santhosh Neelamkavil , Patrick Pinto , Murali Rajogopalan , Unmesh Shah , Francisco Velazquez , Srikanth Venkatraman , Yan Xia
CPC分类号： C07K5/08 , A61K38/06 , A61K45/06 , C07D419/00 , C07D491/22
摘要： The present invention relates to hepatitis C virus (HCV) NS3 protease inhibitors containing a spirocyclic moeity, uses of such compounds, and synthesis of such compounds.
摘要翻译： 本发明涉及含有螺环状的丙型肝炎病毒（HCV）NS3蛋白酶抑制剂，这些化合物的用途，以及这些化合物的合成。
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3.发明申请SUBSTITUTED AZEPINE- AND DIAZEPINE-SULFONAMIDES USEFUL TO INHIBIT 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1 审中-公开用于抑制11BETA-羟基脱氢酶脱氢酶1型的替代亚硒酸和二氮杂萘磺酰胺公开(公告)号：US20110129542A1
公开(公告)日：2011-06-02
申请号：US12672826
申请日：2008-08-12
IPC分类号： A61K31/55 , C07D223/08 , C07D401/12 , C07D409/04 , C07D243/08 , A61K31/551 , C07D403/04 , A61K35/60 , A61P3/00 , A61P3/04 , A61P9/10 , A61P9/12 , A61P3/10 , C12N9/99
CPC分类号： C07D223/08 , C07D223/04 , C07D223/12 , C07D223/30 , C07D243/08 , C07D401/12 , C07D409/04
摘要： In its many embodiments, the present invention relates to a novel class of substituted azepine- and diazepine-sulfonamide compounds useful to inhibit 11β-hydroxysteroid dehydrogenase type-I, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the expression of 11β-hydroxysteroid dehydrogenase type-I using such compounds or pharmaceutical compositions.
摘要翻译： 在其许多实施方案中，本发明涉及可用于抑制11β-羟基类固醇脱氢酶I型的新一类替代的吖庚因和二氮杂 - 磺酰胺化合物，含有该化合物的药物组合物，以及治疗，预防，抑制或抑制 使用这些化合物或药物组合物改善与11＆bgr-羟基类固醇脱氢酶I型的表达相关的一种或多种病症。
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4.发明授权Method of hydroborating alcohols and reducing functional groups using a recyclable fluorous borane-sulfide 失效使用可回收的氟硼烷硫化物加氢醇和还原官能团的方法公开(公告)号：US06849767B2
公开(公告)日：2005-02-01
申请号：US10625982
申请日：2003-07-24
CPC分类号： C07F5/022
摘要： A method of hydroborating an alkene or alkyne, or reducing an organic functionality, oxidizing primary and secondary alcohols using a fluorous borane-sulfide is disclosed. The method includes regeneration and recycling the fluorous borane-sulfide.
摘要翻译： 公开了一种使烯烃或炔烃加氢或减少有机官能团的方法，使用氟代硼烷 - 硫化物氧化伯醇和仲醇。 该方法包括再生和回收氟硼烷硫化物。
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公开(公告)号：US20160229839A1
公开(公告)日：2016-08-11
申请号：US15023833
申请日：2014-09-23
申请人： Eric Mertz , Scott D. Edmondson , Ning Shao , Santhosh Neelamkavil , Corey Poker , Zahid Hussain , Zhuyan Guo , Nancy Jo Kevin , Yi Zang , Jiafang He
发明人： Eric Mertz , Scott D. Edmondson , Ning Shao , Santhosh Neelamkavil , Corey Poker , Zahid Hussain , Zhuyan Guo , Nancy Jo Kevin , Yi Zang , Jiafang He
IPC分类号： C07D401/14 , A01N1/02 , C07D401/06 , C07D401/10 , C07D211/60
CPC分类号： C07D401/14 , A01N1/0226 , C07D211/60 , C07D401/06 , C07D401/10 , C12N9/6443 , C12Y304/21027
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译： 本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。 该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。
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公开(公告)号：US06620972B2
公开(公告)日：2003-09-16
申请号：US10174269
申请日：2002-06-18
申请人： David Crich , Santhosh Neelamkavil
发明人： David Crich , Santhosh Neelamkavil
IPC分类号： C07C31700
CPC分类号： C07C317/04 , C07B39/00 , C07C45/30 , C07C205/44
摘要： A method of oxidizing primary and secondary alcohols to an aldehyde or ketone using a fluorous sulfoxide or a fluorous sulfide is disclosed. The method includes regenerating and recycling the fluorous sulfoxide.
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公开(公告)号：US20160257668A1
公开(公告)日：2016-09-08
申请号：US15027086
申请日：2014-10-06
申请人： Ning SHAO , Scott D. EDMONDSON , Santhosh NEELAMKAVIL , Zhuyan GUO , Eric MERTZ , Yi ZANG , Jiafang HE
发明人： Ning Shao , Scott D. Edmondson , Santhosh Neelamkavil , Zhuyan Guo , Eric Mertz , Yi Zang , Jiafang He
IPC分类号： C07D401/14 , C07C269/06 , C07D401/10
CPC分类号： C07D401/14 , C07C269/06 , C07D401/04 , C07D401/10 , C07D413/14
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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