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公开(公告)号：US06858599B2
公开(公告)日：2005-02-22
申请号：US10026606
申请日：2001-12-27
IPC分类号： C07D471/20 , C07D498/20 , A61K31/33 , A61K31/495 , C07D241/00 , C07D243/00 , C07D491/00
CPC分类号： C07D471/20 , C07D498/20 , G01N2333/96444 , G01N2500/00
摘要： This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.
摘要翻译： 本发明涉及具有以下式（I）表示的螺旋结合物的三环化合物或其盐，其可用作药物，特别是作为活化凝血因子X的抑制剂，其可以口服给药，其表现出强烈的作用 抗凝作用。本发明还涉及一种衍生自化合物并可用于FXa抑制剂分子设计的药效团。
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公开(公告)号：US20110059958A1
公开(公告)日：2011-03-10
申请号：US12744736
申请日：2009-12-03
申请人： Hidemitsu Nishida , Fumihiko Saitoh , Tomokazu Hirabayashi , Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Yan Xia
发明人： Hidemitsu Nishida , Fumihiko Saitoh , Tomokazu Hirabayashi , Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Yan Xia
IPC分类号： A61K31/5377 , C07D413/12 , A61P7/02 , A61P9/10 , A61P9/12 , C07D265/32 , C07D413/10
CPC分类号： C07D401/12 , C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D413/12 , C07D413/14 , C07D417/04
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
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公开(公告)号：US20110135650A1
公开(公告)日：2011-06-09
申请号：US12791464
申请日：2010-06-01
申请人： Samuel CHACKALAMANNIL , Tin-Yau CHAN , Mariappan V. CHELLIAH , Martin C. CLASBY , Michael DWYER , William J. GREENLEE , Tomokazu HIRABAYASHI , Santhosh NEELAMKAVIL , Hidemitsu NISHIDA , Fumihiko SAITOH , Unmesh SHAH , Yan XIA
发明人： Samuel CHACKALAMANNIL , Tin-Yau CHAN , Mariappan V. CHELLIAH , Martin C. CLASBY , Michael DWYER , William J. GREENLEE , Tomokazu HIRABAYASHI , Santhosh NEELAMKAVIL , Hidemitsu NISHIDA , Fumihiko SAITOH , Unmesh SHAH , Yan XIA
IPC分类号： A61K39/395 , C07D413/12 , A61K31/5377 , C07D295/10 , A61K31/5375 , C07D413/10 , C07D413/14 , C07D413/04 , C07D401/12 , A61K31/496 , C07D279/12 , A61K31/54 , A61K31/397 , A61K31/7088 , A61P7/02 , A61P9/00
CPC分类号： C07D413/12 , A61K31/397 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/7088 , A61K39/395 , A61K45/06 , C07D265/32 , C07D413/10 , C07D413/14 , C07D417/10 , A61K2300/00
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供本文所述的式（I）化合物或其药学上可接受的盐或溶剂合物。 本发明还提供包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化改变的方法。
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公开(公告)号：US20050148769A1
公开(公告)日：2005-07-07
申请号：US11012378
申请日：2004-12-16
IPC分类号： C07D471/20 , C07D498/20 , C07D498/10 , C07D491/10
CPC分类号： C07D471/20 , C07D498/20 , G01N2333/96444 , G01N2500/00
摘要： This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.
摘要翻译： 本发明涉及具有以下式（I）表示的螺旋结合物的三环化合物或其盐，其可用作药物，特别是作为活化凝血因子X的抑制剂，其可以口服给药，其表现出强烈的作用 抗凝作用。 本发明还涉及一种衍生自该化合物并可用于FXa抑制剂分子设计的药效团。
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公开(公告)号：US08987242B2
公开(公告)日：2015-03-24
申请号：US12791464
申请日：2010-06-01
申请人： Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Tomokazu Hirabayashi , Santhosh Neelamkavil , Hidemitsu Nishida , Fumihiko Saitoh , Unmesh Shah , Yan Xia
发明人： Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Tomokazu Hirabayashi , Santhosh Neelamkavil , Hidemitsu Nishida , Fumihiko Saitoh , Unmesh Shah , Yan Xia
IPC分类号： A61K31/535 , A01N43/00 , A61K31/33 , C07D413/12 , A61K31/397 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/7088 , A61K39/395 , A61K45/06 , C07D265/32 , C07D413/10 , C07D413/14 , C07D417/10
CPC分类号： C07D413/12 , A61K31/397 , A61K31/496 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/7088 , A61K39/395 , A61K45/06 , C07D265/32 , C07D413/10 , C07D413/14 , C07D417/10 , A61K2300/00
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供本文所述的式（I）化合物或其药学上可接受的盐或溶剂合物。 本发明还提供包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化改变的方法。
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公开(公告)号：US08642582B2
公开(公告)日：2014-02-04
申请号：US12744736
申请日：2009-12-03
申请人： Hidemitsu Nishida , Fumihiko Saitoh , Tomokazu Hirabayashi , Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Yan Xia
发明人： Hidemitsu Nishida , Fumihiko Saitoh , Tomokazu Hirabayashi , Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Yan Xia
IPC分类号： A61K31/535
CPC分类号： C07D401/12 , C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D413/12 , C07D413/14 , C07D417/04
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明提供本文所述的式（I）化合物或其药学上可接受的盐或溶剂合物。 本发明还提供包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维化改变的方法。
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公开(公告)号：US07122662B2
公开(公告)日：2006-10-17
申请号：US11012378
申请日：2004-12-16
IPC分类号： C07D225/04 , C07D267/02 , C07D281/18 , C07D279/00 , C07D237/00
CPC分类号： C07D471/20 , C07D498/20 , G01N2333/96444 , G01N2500/00
摘要： This invention relates to tricyclic compounds having spiro union represented by the following formula (I) or its salt which is useful as a drug, and in particular, as an inhibitor for activated blood coagulation factor X, which can be administered orally and which exhibits strong anticoagulation action. The invention also relates to a pharmacophore which was derived from the compound and is useful in molecular designing of the FXa inhibitor.
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8.发明授权Character recognition system using the generalized hough transformation and method 失效使用通用的HOUGH变换和方法的字符识别系统
公开(公告)号：US5220621A
公开(公告)日：1993-06-15
申请号：US738391
申请日：1991-07-31
申请人： Fumihiko Saitoh
发明人： Fumihiko Saitoh
CPC分类号： G06K9/6205
摘要： A character recognition system and method using the generalized Hough transform are disclosed. A template table which stores edge point parameters to be used for the generalized Hough transform is compressed so as to include only predetermined parameters, and is then divided into a plurality of template tables which are respectively loaded in the memories of a plurality of subprocessors operating in parallel under the control of a main processor. In performing recognition processing, these subprocessors operate in parallel according to their related partial template tables. Character recognition using the generalized Hough transform provides a high rate of character recognition. Also, parallel processing using the compressed template tables and partial template tables helps shorten table search time and computation time, thereby increasing processing efficiency.
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