Invention Grant
- Patent Title: Heterocyclic compounds as ERK inhibitors
- Patent Title (中): 杂环化合物作为ERK抑制剂
-
Application No.: US13703250Application Date: 2011-06-22
-
Publication No.: US08999957B2Publication Date: 2015-04-07
- Inventor: Yongqi Deng , Liang Zhu , Gerald W. Shipps, Jr. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
- Applicant: Yongqi Deng , Liang Zhu , Gerald W. Shipps, Jr. , Sie-Mun Lo , Binyuan Sun , Xiaohua Huang , Corey Bienstock , Alan B. Cooper , Xiaolei Gao , Xin Yao , Hugh Y. Zhu , Joseph M. Kelly , Sobhana Babu Boga , Abdul-Basit Alhassan , Jayaram R. Tagat , Umar Faruk Mansoor , Kevin J. Wilson , Brendan M. O'Boyle , Matthew Hersh Daniels , Adam Schell , Phieng Siliphaivanh , Christian Fischer
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Richard S. Parr; Laura M. Ginkel
- International Application: PCT/US2011/041396 WO 20110622
- International Announcement: WO2011/163330 WO 20111229
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D409/14 ; C07D413/14 ; C07D417/14 ; C07D471/04 ; C07D401/14 ; C07D405/14 ; A61K31/454 ; A61K31/4545 ; A61K31/506 ; A61K31/5377 ; A61K31/55 ; A61K31/551 ; A61K31/695 ; A61K45/06 ; C07F7/18
Abstract:
The present invention provides a compound of the Formula I: (Formular I should be inserted here) or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2 and R3 are as defined herein. The compounds are ERK inhibitors. Also disclosed are pharmaceutical compositions comprising the above compounds and methods of treating cancer using the same.
Public/Granted literature
- US20130096084A1 NOVEL HETEROCYCLIC COMPOUNDS AS ERK INHBITORS Public/Granted day:2013-04-18
Information query
