发明授权
US09012159B2 Cell based screening assays for the triglyceride synthesis pathway
有权
甘油三酯合成途径的基于细胞的筛选试验
- 专利标题： Cell based screening assays for the triglyceride synthesis pathway
- 专利标题（中）： 甘油三酯合成途径的基于细胞的筛选试验
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申请号： US12683527申请日： 2010-01-07
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公开(公告)号： US09012159B2公开(公告)日： 2015-04-21
- 发明人: Jian-Shen Qi , Wensheng Lang , Margery A. Connelly
- 申请人： Jian-Shen Qi , Wensheng Lang , Margery A. Connelly
- 申请人地址： US NJ Raritan
- 专利权人： Janssen Research & Development, LLC
- 当前专利权人： Janssen Research & Development, LLC
- 当前专利权人地址： US NJ Raritan
- 代理机构： Johnson & Johnson
- 代理商 Bernard F. Plantz
- 主分类号： G01N33/567
- IPC分类号： G01N33/567 ; G01N33/50 ; C12Q1/48 ; G01N33/60 ; G01N33/92
摘要：
A method for identifying a compound which modulates the activity of acyl-coA: diacylglycerol acyltransferase comprises the steps of contacting a stable isotope labeled fatty acid with cells in either presence or absence of the compound, extracting the cells with isopropyl alcohol, and determining the level of a stable isotope labeled triglyceride in the presence or absence of the compound; wherein a change in the level of the stable isotope labeled triglyceride indicates that the compound modulates the DGAT activity.
公开/授权文献
- US20100196930A1 CELL BASED ASSAYS FOR THE TRIGLYCERIDE SYNTHESIS PATHWAY 公开/授权日：2010-08-05
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