发明授权
US09139812B2 CD49F promoting proliferation, multipotency and reprogramming of adult stem cells through PI3K/AKT/GSK3 pathway
有权
CD49F通过PI3K / AKT / GSK3途径促进成体干细胞的增殖，多能性和重编程
- 专利标题： CD49F promoting proliferation, multipotency and reprogramming of adult stem cells through PI3K/AKT/GSK3 pathway
- 专利标题（中）： CD49F通过PI3K / AKT / GSK3途径促进成体干细胞的增殖，多能性和重编程
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申请号： US13638262申请日： 2011-02-18
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公开(公告)号： US09139812B2公开(公告)日： 2015-09-22
- 发明人: Kyung Sun Kang , Kyung Rok Yu
- 申请人： Kyung Sun Kang , Kyung Rok Yu
- 申请人地址： KR Seoul
- 专利权人： KANG STEM HOLDINGS CO., LTD
- 当前专利权人： KANG STEM HOLDINGS CO., LTD
- 当前专利权人地址： KR Seoul
- 代理机构： Cooley LLP
- 优先权： KR10-2010-0014771 20100218
- 国际申请： PCT/KR2011/001103 WO 20110218
- 国际公布： WO2011/102680 WO 20110825
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; C12Q1/24 ; G01N33/50 ; C12N5/0775 ; A61K35/12
摘要：
The present invention relates to a method for obtaining adult stem cells, which have a surface antigen of CD49f, excellent formation of spheres due to sphere formation and high expression of OCT4 and SOX2, from a cell source including stem cells, and a cell therapeutic agent containing adult stem cells obtained by the method or cells differentiated therefrom as an active ingredient.According to the present invention, adult stem cells derived from spheres are suitable for mass culture of adult stem cells because of more rapid growth thereof compared with stem cells obtained by a known adhesive culture method, have a specific surface antigen so as to be homogeneously obtained by using the specific surface antigen, and are useful for preparing a cell therapeutic agent using the same because of excellent differentiation thereof.
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