发明授权
- 专利标题： Establishment of rhesus monkey model of autoimmunity type 1 diabetes
- 专利标题（中）： 建立自身免疫1型糖尿病恒河猴模型
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申请号： US13637125申请日： 2010-03-26
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公开(公告)号： US09186421B2公开(公告)日： 2015-11-17
- 发明人: Yanrong Lu , Jingqiu Cheng , Shaoping Deng , Younan Chen , Bole Tian , Gang Mai , Yan Ren , Li Wang , Hongxia Li , Lingling Wei , Xi Jin , Chaofeng Qiao , Wensheng Zhang , Sirong He , Li Zeng
- 申请人： Yanrong Lu , Jingqiu Cheng , Shaoping Deng , Younan Chen , Bole Tian , Gang Mai , Yan Ren , Li Wang , Hongxia Li , Lingling Wei , Xi Jin , Chaofeng Qiao , Wensheng Zhang , Sirong He , Li Zeng
- 申请人地址： CN Sichuan
- 专利权人： West China Hospital, Sichuan University
- 当前专利权人： West China Hospital, Sichuan University
- 当前专利权人地址： CN Sichuan
- 代理机构： Cesari and McKenna, LLP
- 国际申请： PCT/CN2010/000378 WO 20100326
- 国际公布： WO2011/116501 WO 20110929
- 主分类号： A01K67/00
- IPC分类号： A01K67/00 ; A61K49/00 ; A01K67/027
摘要：
Use of low dose streptozocin in the preparation of an animal model for screening drugs for treatment of antoimmune type 1 diabetes is disclosed, in which streptozocin is administrated intravenously at a dose of 15-30 mg/kg per time for 5 days and administrated again on the 7th day and 14th day after last time of offering drug. A method for preparing rhesus monkey model of autoimmune type 1 diabetes and autoimmune type 1 diabetes animal model obtained are also disclosed.
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