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公开(公告)号：US20240261194A1
公开(公告)日：2024-08-08
申请号：US18641887
申请日：2024-04-22
发明人： Yan JIANG , Yan LIU , Wei CUN , Menghang WU , Hua CAO , Dayong WU , Qijie HUANG
IPC分类号： A61J15/00
CPC分类号： A61J15/0061
摘要： A fixing device for double-tube intubation includes a fitting component and a fixing frame arranged on the fitting component, where both ends of the fitting component are connected with a connecting portion, through which the fitting component is fixed to philtrum below nares. The fixing frame includes at least two pressing portions, one side of each of the pressing portions is connected mutually while the other side is mutually and detachably connected, and containing portions for placing the pipeline are arranged between the two pressing portions.
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公开(公告)号：US20220135526A1
公开(公告)日：2022-05-05
申请号：US17427521
申请日：2020-01-21
发明人： Bowen KE , Jin LIU , Wensheng ZHANG , Jun YANG , Lei TANG
IPC分类号： C07D211/60 , C07D205/04 , C07D207/16 , C07D223/06 , C07D413/06 , C07D413/12
摘要： A quaternary ammonium salt compound of formula I is fast-acting and has a long-term local anaesthetic effect after a single administration, the sensory nerve block time being longer than the motor nerve block time, has both a long-acting local anaesthetic effect and a selective local anaesthetic effect, and also significantly reduces the side effects of quaternary ammonium salt compounds with the structural features of surfactants and is highly safe; thus, the compound of formula I and the pharmaceutically acceptable salt thereof can be used for the preparation of saft drugs having a long-term local anaesthetic effect and a selective local anaesthetic effect
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公开(公告)号：US20210214304A1
公开(公告)日：2021-07-15
申请号：US17044520
申请日：2019-07-24
发明人： Jin LIU , Jun YANG , Wensheng ZHANG , Bowen KE , Weiyi ZHANG , Cheng ZHOU , Lei TANG
IPC分类号： C07D211/38 , C07D295/15 , C07D333/20 , C07D307/52 , C07D409/12 , C07D407/12
摘要： A dication compound represented by formula (I), stereoisomers having the structure of formula (I) or a mixture of the stereoisomers, a pharmaceutically acceptable salt, a solvate, or a eutectic crystal, and a composition thereof, and use of a composition, are capable of producing neuromuscular junction retardation, formed of same with a pharmaceutically acceptable carrier in the field of preparation of a medicament for muscular flaccidity.
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公开(公告)号：US20210101944A1
公开(公告)日：2021-04-08
申请号：US16989654
申请日：2020-08-10
发明人： Xiaofeng LU , Hao YANG , Ze TAO , Jingqiu CHENG
IPC分类号： C07K14/315 , C07K14/705 , C07K16/28 , A61K38/17 , A61K38/16 , A61P35/00
摘要： A recombinant protein includes a TRAIL domain and an IgG binding domain IgBD. In the recombinant protein, IgBD can be fused at the N-terminus or C-terminus of the TRAIL domain. The anti-tumor effect of the recombinant protein after binding to endogenous or exogenous IgG is significantly stronger than that of TRAIL, and can be used in the treatment of cell proliferative diseases with high expression of death receptors.
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![[1,2,4] triazolo [1,5-a] pyridine derivative and crystalline form thereof](/abs-image/US/2020/10/27/US10815231B2/abs.jpg.150x150.jpg)
公开(公告)号：US10815231B2
公开(公告)日：2020-10-27
申请号：US16314329
申请日：2016-08-16
发明人： Weimin Li , Yang He , Li Zhang , Bojiang Chen , Zhixin Qiu
IPC分类号： C07D471/04 , A61P35/00
摘要： The present invention discloses [1,2,4]triazolo[1,5-a]pyridine derivatives, as well as the crystalline form thereof. Compounds provided in the present invention have significant inhibitory effects on tumor cells, can be used for the prevention and/or treatment of tumor-related diseases, especially lung cancer, and have wide application prospects.
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6.发明申请公开(公告)号：US20060264370A1
公开(公告)日：2006-11-23
申请号：US11338117
申请日：2006-01-23
申请人： Xiao-Qing Qiu
发明人： Xiao-Qing Qiu
CPC分类号： C07K14/40 , A61K38/00 , C07K14/245 , C07K2319/01
摘要： The present invention is directed to fusion peptides comprising a fungal targeting agent and a channel-forming domain consisting essentially of amino acids 451-626 of colicin Ia, as well as the polynucleotides encoding the peptides of the invention. The fusion peptides of the peptides of the present invention are particularly useful for the treatment of fungal infections in a wide variety of organisms.
摘要翻译： 本发明涉及包含真菌靶向剂和基本上由大肠杆菌素Ia的氨基酸451-626组成的通道形成结构域的融合肽，以及编码本发明的肽的多核苷酸。 本发明的肽的融合肽特别可用于治疗各种生物体中的真菌感染。
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7.发明公开公开(公告)号：US20240309460A1
公开(公告)日：2024-09-19
申请号：US18575172
申请日：2022-05-10
发明人： Jingsi DONG
IPC分类号： C12Q1/6886 , C12Q1/686
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/158
摘要： A reagent for detecting piR-hsa-120522 in plasma is used in the preparation of a non-small cell lung cancer screening or diagnosis kit. Compared with benign nodules and healthy people, piR-hsa-120522 has a significantly higher expression level in plasma of patients with non-small cell lung cancer and precancerous lesions (P
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8.发明公开公开(公告)号：US20240277769A1
公开(公告)日：2024-08-22
申请号：US18571541
申请日：2022-06-15
发明人： Xudong ZHAO , Bin SUN
IPC分类号： A61K35/17 , A61K39/00 , A61P35/04 , C07K14/725 , C07K16/28 , C12N5/0783 , C12N15/86
CPC分类号： A61K35/17 , A61K39/4611 , A61K39/4631 , A61K39/464402 , A61K39/464476 , A61P35/04 , C07K14/7051 , C07K16/28 , C12N5/0636 , C12N15/86 , A61K2239/13 , A61K2239/21 , C07K2317/53 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N2740/15043
摘要： A preparation and an application of a chimeric antigen receptor immune cell constructed on the basis of a C-type lectin superfamily low-density lipoprotein receptor (LOX1) are provided. Specifically provided is a chimeric antigen receptor (CAR) modified on the basis of LOX1. The CAR contains an extracellular binding domain capable of specifically targeting LOX1 receptors such as heat shock protein, oxidized low-density lipoprotein (oxLDL) and phosphatidylserine. The CAR immune cell has strong specificity and target affinity, and therefore has strong target cell killing capability and a high degree of safety.
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公开(公告)号：US20230416290A1
公开(公告)日：2023-12-28
申请号：US18335136
申请日：2023-06-15
发明人： Zhiyao He , Yuquan Wei
IPC分类号： C07H15/18 , C08B37/00 , C07H15/10 , C07H15/04 , C07C269/06
CPC分类号： C07H15/18 , C08B37/0087 , C07H15/10 , C07H15/04 , C07C269/06
摘要： Disclosed is a method for preparing an N-acetyl-D-galactosamine tripolymer precursor. In the preparation of the tripolymer precursor, a compound 4 is prepared by the following steps: adding a compound 3, a 4Å molecular sieve powder, and a reaction solvent into a reactor; inflating and changing protective gas for 3 times; stirring; firstly adding an enol, followed by slowly dropping trimethylsilyl trifluoromethanesulfonate; after a reaction, quenching the reaction with an alkali solution; and performing extraction, separating liquid, washing, drying, filtration, etc., so as to obtain the compound 4. According to the present disclosure, the problems of various production processes, more times of column chromatography for purification of products accompanied by lower yields in the prior art are solved.
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10.发明公开公开(公告)号：US20230273973A1
公开(公告)日：2023-08-31
申请号：US18003654
申请日：2022-09-29
发明人： Yongkang WU , Yuxiang WU
摘要： An index homogenization conversion method, a method and device for homogenization conversion of same index detected by different equipment, electronic equipment, and a comparison sample determination method are provided. The index homogenization conversion method includes acquiring an actually-measured signal value; determining corresponding concentration thereof on a first standard curve; obtaining a first target arc-line segment thereof according to first and second end points of the first standard curve, and obtaining a second target-arc line segment thereof according to the first end point and an end point of test sample on the first standard curve; obtaining a third target arc-line segment according to first and second end points of the second standard curve; determining an arc length equation of a fourth target arc-line segment according to the first, second and third target arc-line segments; and determining a homogenization concentration corresponding to the actually-measured signal value according to the arc length equation.
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