发明授权
- 专利标题: Methods and compositions for mesenchymal stem cell proliferation
- 专利标题(中): 间充质干细胞增殖的方法和组成
-
申请号: US14004776申请日: 2012-04-02
-
公开(公告)号: US09193954B2公开(公告)日: 2015-11-24
- 发明人: Michael Hoffman , Danielle Benoit
- 申请人: Michael Hoffman , Danielle Benoit
- 申请人地址: US NY Rochester
- 专利权人: University of Rochester
- 当前专利权人: University of Rochester
- 当前专利权人地址: US NY Rochester
- 代理机构: Hodgson Russ LLP
- 国际申请: PCT/US2012/031806 WO 20120402
- 国际公布: WO2012/135813 WO 20121004
- 主分类号: C12N5/071
- IPC分类号: C12N5/071 ; C12N5/00 ; C12N5/0775
摘要:
Provided is a method for increasing proliferation of mesenchymal stem cells. The method entails contacting the cells with 6-bromoindirubin-3′-oxime (BIO). This results in robust proliferation and “stemness” in a dose-dependent fashion, as indicated by the gene expression of two stem cell genes: Sox2 and Nanog.
公开/授权文献
信息查询