发明授权
- 专利标题： Aniline derivatives, their preparation and their therapeutic application
- 专利标题（中）： 苯胺衍生物，其制备及其治疗应用
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申请号： US14344925申请日： 2012-09-07
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公开(公告)号： US09249085B2公开(公告)日： 2016-02-02
- 发明人: John Feutrill , Caroline Leriche , David Middlemiss
- 申请人： John Feutrill , Caroline Leriche , David Middlemiss
- 申请人地址： FR Paris
- 专利权人： FOVEA PHARMACEUTICALS
- 当前专利权人： FOVEA PHARMACEUTICALS
- 当前专利权人地址： FR Paris
- 代理机构： Morrison & Foerster LLP
- 优先权： EP11306170 20110916; EP12305130 20120203; EP12305626 20120604
- 国际申请： PCT/EP2012/067473 WO 20120907
- 国际公布： WO2013/037705 WO 20130321
- 主分类号： C07C217/84
- IPC分类号： C07C217/84 ; C07C235/56 ; C07C233/75 ; C07C255/59 ; C07C63/72 ; C07C13/02 ; C07C13/08 ; C07C235/20 ; C07C237/30 ; A61K31/196 ; A61K45/06 ; A61K31/216 ; C07C215/76 ; C07C65/105 ; C07C65/24 ; A61K31/165 ; A61K31/277 ; A61K31/5375 ; C07C213/02 ; C07C213/08 ; C07C253/30 ; C07C255/57 ; C07C255/58 ; C07D295/088
摘要：
The present invention relates to aniline derivatives of formula (I), to their preparation and to their therapeutic application, for example in treating glaucoma: Formula (I), R1a represents H, an halogen, a (C1-C6)alkyl or a CN; R1b represents H, an halogen or a (C1-C6)alkyl; R1c represents H or a (C1-C6)alkyl; R2 represents H, an halogen, an OH, an O—(C1-C6)alkyl or (C1-C6)alkyl; R3 represents H, an halogen, a (C1-C6)alkyl, an OH, an O—(C1-C6)alkyl, a CONH2 or CN; R4 represents H, an halogen or a (C1-C6)alkyl; R5 represents H or F: R7 represents H or F; R8 represents H or F; R9 represents H or (C1-C6)alkyl, or one of its enantiomers.