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    Process for preparing 3-(N,N-disubstituted amino)phenol
    6.
    发明授权
    Process for preparing 3-(N,N-disubstituted amino)phenol 失效
    制备3-（N，N-二取代氨基）苯酚的方法

    公开(公告)号：US5710335A

    公开(公告)日：1998-01-20

    申请号：US725505

    申请日：1996-10-04

    申请人： Kenichiro Horiuchi ,  Bunji Sawano ,  Nobuaki Sasaki ,  Mansuke Matsumoto

    发明人： Kenichiro Horiuchi ,  Bunji Sawano ,  Nobuaki Sasaki ,  Mansuke Matsumoto

    IPC分类号： C07C213/02 ,  C07C215/76 ,  C07C209/18

    CPC分类号： C07C215/76 ,  C07C213/02

    摘要： A process for preparing a 3-(N,N-disubstituted amino)phenol is herein disclosed which comprises reacting resorcin with a primary amine represented by formula (2): R.sup.1 NH.sub.2 (2) wherein R.sup.1 is an alkyl group, a cycloalkyl group, an alkenyl group, an alkoxyalkyl group, an aryl group or an aralkyl group, terminating the reaction when the conversion of resorcin is 50 mol % or more and when the amount of an N,N'-disubstituted-m-phenylenediamine as a by-product is 2 mol % or less of the amount of used resorcin, adding an alkyl halide represented by formula (3): R.sup.2 X (3) wherein R.sup.2 is an alkyl group or a cycloalkyl group; and X is a halogen atom, to the obtained reaction mixture, adding an aqueous alkaline solution to the resultant reaction mixture to dissolve unreacted resorcin in the aqueous phase, extracting the 3-(N,N-disubstituted amino)phenol with an organic solvent, and then recovering unreacted resorcin from the aqueous phase. According to this process, the high-purity 3-(N,N-disubstituted amino)phenol can be prepared from resorcin in a substantially high yield, the production of by-products being inhibited.

    摘要翻译： 本文公开了制备3-（N，N-二取代的氨基）苯酚的方法，其包括使间苯二酚与由式（2）表示的伯胺反应：其中R 1是烷基，环烷基， 烯基，烷氧基烷基，芳基或芳烷基，当间苯二酚的转化率为50摩尔％以上时，当N，N'-二取代的间苯二胺作为副产物时，终止反应 是使用间苯二酚的量的2mol％以下，加入式（3）表示的烷基卤：R2X（3）其中R2是烷基或环烷基; 和X是卤素原子，向所得反应混合物中加入碱性水溶液至所得反应混合物中以在水相中溶解未反应的间苯二酚，用有机溶剂萃取3-（N，N-二取代的氨基）苯酚， 然后从水相中回收未反应的间苯二酚。 根据该方法，高纯度3-（N，N-二取代氨基）苯酚可以以高产率从间苯二酚制备，副产物的产生被抑制。