Invention Grant
- Patent Title: RNA-guided human genome engineering
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Application No.: US14319255Application Date: 2014-06-30
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Publication No.: US09260723B2Publication Date: 2016-02-16
- Inventor: Prashant G. Mali , George M. Church , Luhan Yang
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Banner & Witcoff, Ltd.
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C12N9/14 ; C12N9/22 ; C07H21/02 ; C07H21/04 ; C12N15/87 ; C12N15/01 ; C12N15/81 ; C12N15/82 ; C12N15/10 ; C12N15/63 ; C12N15/90
Abstract:
A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner.
Public/Granted literature
- US20140342458A1 RNA-Guided Human Genome Engineering Public/Granted day:2014-11-20
Information query
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